Incidence of Invasive Pneumococcal Disease among Individuals with Sickle Cell Disease before and after the Introduction of the Pneumococcal Conjugate Vaccine

Background. We sought to determine the incidence of invasive pneumococcal disease (IPD) among individuals with sickle cell disease (SCD) before and after the introduction of the pneumococcal conjugate vaccine (PCV). Methods. Individuals with SCD who were enrolled in Tennessee Medicaid from January 1...

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Bibliographic Details
Published in:Clinical infectious diseases 2007-06, Vol.44 (11), p.1428-1433
Main Authors: Halasa, Natasha B., Shankar, Sadhna M., Talbot, Thomas R., Arbogast, Patrick G., Mitchel, Ed F., Wang, Winfred C., Schaffner, William, Craig, Allen S., Griffin, Marie R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia, Sickle Cell - complications
Articles and Commentaries
Child
Child, Preschool
Children
Children & youth
Clinical outcomes
Conjugate vaccines
Diagnostic tests
Epidemiology
Human subjects
Humans
Incidence
Infant
Infections
Medicaid
Pediatrics
Penicillin
Penicillins - therapeutic use
Pneumococcal Infections - complications
Pneumococcal Infections - epidemiology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines
Pneumonia
Preventive medicine
Serotyping
Sickle cell disease
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - isolation & purification
Tennessee - epidemiology
Vaccination
Vaccines
Vaccines, Conjugate
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Summary:Background. We sought to determine the incidence of invasive pneumococcal disease (IPD) among individuals with sickle cell disease (SCD) before and after the introduction of the pneumococcal conjugate vaccine (PCV). Methods. Individuals with SCD who were enrolled in Tennessee Medicaid from January 1995 through December 2004 were identified using SCD-specific International Classification of Diseases, Ninth Revision, Clinical Modification codes. Population-based surveillance data were used to identify individuals with IPD and were linked to patients with SCD in the Tennessee Medicaid database to determine incidence rates of IPD. Clinical data were collected on all subjects with IPD, and antibiotic susceptibility testing and serotyping were performed on all available pneumococcal isolates. Results. We identified 2026 individuals with SCD, who constituted 13,687 person-years of follow-up. During the study period, 37 individuals with SCD developed IPD, and 21 of these patients were aged
ISSN:1058-4838
1537-6591
DOI:10.1086/516781