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Associations of Plasma-Soluble Fas Ligand with Aging and Age-Related Macular Degeneration

To evaluate the associations between plasma-soluble Fas ligand (sFasL) and age-related macular degeneration (AMD). Plasma samples were obtained from 230 individuals (age range, 45-85), with or without AMD. The concentrations of sFasL were determined by an enzyme-linked immunosorbent assay (ELISA). T...

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Published in:	Investigative ophthalmology & visual science 2008-04, Vol.49 (4), p.1345-1349
Main Authors:	Jiang, Shunai, Moriarty-Craige, Siobhan E, Li, Chun, Lynn, Michael J, Cai, Jiyang, Jones, Dean P, Sternberg, Paul
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Language:	English
Subjects:	Aged Aged, 80 and over Aging - physiology Biological and medical sciences Enzyme-Linked Immunosorbent Assay Eye and associated structures. Visual pathways and centers. Vision Fas Ligand Protein - blood Female Fundamental and applied biological sciences. Psychology Humans Macular Degeneration - blood Male Medical sciences Middle Aged Ophthalmology Retinopathies Vertebrates: nervous system and sense organs
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container_title	Investigative ophthalmology & visual science
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creator	Jiang, Shunai Moriarty-Craige, Siobhan E Li, Chun Lynn, Michael J Cai, Jiyang Jones, Dean P Sternberg, Paul
description	To evaluate the associations between plasma-soluble Fas ligand (sFasL) and age-related macular degeneration (AMD). Plasma samples were obtained from 230 individuals (age range, 45-85), with or without AMD. The concentrations of sFasL were determined by an enzyme-linked immunosorbent assay (ELISA). The measured sFasL levels were transformed into cubic roots and were fitted into linear regression models against AMD status, with adjustment for age and sex. Plasma sFasL increased with age and AMD. There was a linear correlation between age and the cubic roots of sFasL. The plasma sFasL concentrations in non-AMD subjects ranged from 0 to 1.63 ng/mL (median, 0.69 ng/mL), whereas in patients with AMD, sFasL ranged from 0 to 2.43 ng/mL (median, 0.18 ng/mL). Between the ages of 61 and 84, the subjects with AMD had significantly higher sFasL than did the non-AMD subjects. There was a sexual dimorphism of the plasma sFasL levels. In non-AMD subjects, sFasL was lower in the females. In patients with AMD, sFasL was higher in the females. An elevation of plasma sFasL with aging may play a role in the development of AMD and is a potential peripheral marker for monitoring disease progression.
doi_str_mv	10.1167/iovs.07-0308
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Plasma samples were obtained from 230 individuals (age range, 45-85), with or without AMD. The concentrations of sFasL were determined by an enzyme-linked immunosorbent assay (ELISA). The measured sFasL levels were transformed into cubic roots and were fitted into linear regression models against AMD status, with adjustment for age and sex. Plasma sFasL increased with age and AMD. There was a linear correlation between age and the cubic roots of sFasL. The plasma sFasL concentrations in non-AMD subjects ranged from 0 to 1.63 ng/mL (median, 0.69 ng/mL), whereas in patients with AMD, sFasL ranged from 0 to 2.43 ng/mL (median, 0.18 ng/mL). Between the ages of 61 and 84, the subjects with AMD had significantly higher sFasL than did the non-AMD subjects. There was a sexual dimorphism of the plasma sFasL levels. In non-AMD subjects, sFasL was lower in the females. In patients with AMD, sFasL was higher in the females. An elevation of plasma sFasL with aging may play a role in the development of AMD and is a potential peripheral marker for monitoring disease progression.</description><identifier>ISSN: 0146-0404</identifier><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.07-0308</identifier><identifier>PMID: 18385048</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Aged ; Aged, 80 and over ; Aging - physiology ; Biological and medical sciences ; Enzyme-Linked Immunosorbent Assay ; Eye and associated structures. Visual pathways and centers. Vision ; Fas Ligand Protein - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Macular Degeneration - blood ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; Retinopathies ; Vertebrates: nervous system and sense organs</subject><ispartof>Investigative ophthalmology & visual science, 2008-04, Vol.49 (4), p.1345-1349</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-54df3b89a28568e391650683bcefe58ca853883844f33734f93a9d73cee6d3943</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20277879$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18385048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Shunai</creatorcontrib><creatorcontrib>Moriarty-Craige, Siobhan E</creatorcontrib><creatorcontrib>Li, Chun</creatorcontrib><creatorcontrib>Lynn, Michael J</creatorcontrib><creatorcontrib>Cai, Jiyang</creatorcontrib><creatorcontrib>Jones, Dean P</creatorcontrib><creatorcontrib>Sternberg, Paul</creatorcontrib><title>Associations of Plasma-Soluble Fas Ligand with Aging and Age-Related Macular Degeneration</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To evaluate the associations between plasma-soluble Fas ligand (sFasL) and age-related macular degeneration (AMD). Plasma samples were obtained from 230 individuals (age range, 45-85), with or without AMD. The concentrations of sFasL were determined by an enzyme-linked immunosorbent assay (ELISA). The measured sFasL levels were transformed into cubic roots and were fitted into linear regression models against AMD status, with adjustment for age and sex. Plasma sFasL increased with age and AMD. There was a linear correlation between age and the cubic roots of sFasL. The plasma sFasL concentrations in non-AMD subjects ranged from 0 to 1.63 ng/mL (median, 0.69 ng/mL), whereas in patients with AMD, sFasL ranged from 0 to 2.43 ng/mL (median, 0.18 ng/mL). Between the ages of 61 and 84, the subjects with AMD had significantly higher sFasL than did the non-AMD subjects. There was a sexual dimorphism of the plasma sFasL levels. In non-AMD subjects, sFasL was lower in the females. In patients with AMD, sFasL was higher in the females. An elevation of plasma sFasL with aging may play a role in the development of AMD and is a potential peripheral marker for monitoring disease progression.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fas Ligand Protein - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Macular Degeneration - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Retinopathies</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0146-0404</issn><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpFkM1v1DAQRy0EotvCjTPyBU5NO87YsXNcFQpIi4r4OHCyvM4ka-RNWjtpxH9Plq7a02ikp6efHmNvBFwIUenLMNznC9AFIJhnbCWUKgulDT5nKxCyKkCCPGGnOf8BKIUo4SU7EQaNAmlW7Pc658EHN4ahz3xo-bfo8t4VP4Y4bSPxa5f5JnSub_gcxh1fd6Hv-OFdd1R8p-hGavhX56foEv9AHfWU_ttesReti5leH-8Z-3X98efV52Jz8-nL1XpTeFQwFko2LW5N7UqjKkNYi0pBZXDrqSVlvDMKzTJXyhZRo2xrdHWj0RNVDdYSz9j7B-9tGu4myqPdh-wpRtfTMGWrQVZVDWIBzx9An4acE7X2NoW9S3-tAHtIaQ8pLWh7SLngb4_eabun5gk-tluAd0fAZe9im1zvQ37kSii1Nrp-GrgL3W4OiewSOMZFK-w8z7K20gqUCv8BFZeIow</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Jiang, Shunai</creator><creator>Moriarty-Craige, Siobhan E</creator><creator>Li, Chun</creator><creator>Lynn, Michael J</creator><creator>Cai, Jiyang</creator><creator>Jones, Dean P</creator><creator>Sternberg, Paul</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Associations of Plasma-Soluble Fas Ligand with Aging and Age-Related Macular Degeneration</title><author>Jiang, Shunai ; Moriarty-Craige, Siobhan E ; Li, Chun ; Lynn, Michael J ; Cai, Jiyang ; Jones, Dean P ; Sternberg, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-54df3b89a28568e391650683bcefe58ca853883844f33734f93a9d73cee6d3943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fas Ligand Protein - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Macular Degeneration - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Retinopathies</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Shunai</creatorcontrib><creatorcontrib>Moriarty-Craige, Siobhan E</creatorcontrib><creatorcontrib>Li, Chun</creatorcontrib><creatorcontrib>Lynn, Michael J</creatorcontrib><creatorcontrib>Cai, Jiyang</creatorcontrib><creatorcontrib>Jones, Dean P</creatorcontrib><creatorcontrib>Sternberg, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Shunai</au><au>Moriarty-Craige, Siobhan E</au><au>Li, Chun</au><au>Lynn, Michael J</au><au>Cai, Jiyang</au><au>Jones, Dean P</au><au>Sternberg, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of Plasma-Soluble Fas Ligand with Aging and Age-Related Macular Degeneration</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>49</volume><issue>4</issue><spage>1345</spage><epage>1349</epage><pages>1345-1349</pages><issn>0146-0404</issn><issn>1552-5783</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>To evaluate the associations between plasma-soluble Fas ligand (sFasL) and age-related macular degeneration (AMD). Plasma samples were obtained from 230 individuals (age range, 45-85), with or without AMD. The concentrations of sFasL were determined by an enzyme-linked immunosorbent assay (ELISA). The measured sFasL levels were transformed into cubic roots and were fitted into linear regression models against AMD status, with adjustment for age and sex. Plasma sFasL increased with age and AMD. There was a linear correlation between age and the cubic roots of sFasL. The plasma sFasL concentrations in non-AMD subjects ranged from 0 to 1.63 ng/mL (median, 0.69 ng/mL), whereas in patients with AMD, sFasL ranged from 0 to 2.43 ng/mL (median, 0.18 ng/mL). Between the ages of 61 and 84, the subjects with AMD had significantly higher sFasL than did the non-AMD subjects. There was a sexual dimorphism of the plasma sFasL levels. In non-AMD subjects, sFasL was lower in the females. In patients with AMD, sFasL was higher in the females. An elevation of plasma sFasL with aging may play a role in the development of AMD and is a potential peripheral marker for monitoring disease progression.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>18385048</pmid><doi>10.1167/iovs.07-0308</doi><tpages>5</tpages></addata></record>
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subjects	Aged Aged, 80 and over Aging - physiology Biological and medical sciences Enzyme-Linked Immunosorbent Assay Eye and associated structures. Visual pathways and centers. Vision Fas Ligand Protein - blood Female Fundamental and applied biological sciences. Psychology Humans Macular Degeneration - blood Male Medical sciences Middle Aged Ophthalmology Retinopathies Vertebrates: nervous system and sense organs
title	Associations of Plasma-Soluble Fas Ligand with Aging and Age-Related Macular Degeneration
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