Integrative Metabolic Regulation of Peripheral Tissue Fatty Acid Oxidation by the Src Kinase Family Member Fyn

Mice null for Fyn (a member of the Src family of nonreceptor tyrosine kinases) display a reduced percentage of adipose mass associated with decreased adipocyte cell size. In parallel, there is a substantial reduction in fasting plasma glucose, insulin, triglycerides, and free fatty acids concomitant...

Full description

Saved in:
Bibliographic Details
Published in:Cell metabolism 2007-05, Vol.5 (5), p.371-381
Main Authors: Bastie, Claire C., Zong, Haihong, Xu, Jun, Busa, Bhavin, Judex, Stefan, Kurland, Irwin J., Pessin, Jeffrey E.
Format: Article
Language:English
Subjects:
Adenylate Kinase - metabolism
Adipose Tissue - metabolism
Animals
Blotting, Western
Calorimetry, Indirect
Fatty Acids - metabolism
Glucose
HUMDISEASE
Insulin - metabolism
Mice
Muscle, Skeletal - metabolism
Oxidation-Reduction
Proto-Oncogene Proteins c-fyn - genetics
Proto-Oncogene Proteins c-fyn - metabolism
SIGNALING
Tomography, X-Ray Computed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mice null for Fyn (a member of the Src family of nonreceptor tyrosine kinases) display a reduced percentage of adipose mass associated with decreased adipocyte cell size. In parallel, there is a substantial reduction in fasting plasma glucose, insulin, triglycerides, and free fatty acids concomitant with decreased intrahepatocellular and intramyocellular lipid accumulation. Importantly, the Fyn null mice exhibit improved glucose tolerance resulting from increased peripheral tissue (adipose and skeletal muscle) insulin sensitivity with a very small effect in the liver. Moreover, whole-body, adipose, and skeletal muscle fatty acid uptake and oxidation are increased along with AMP kinase activation and acetyl-CoA carboxylase inhibition. Together, these data demonstrate crosstalk between Src-family kinase activity and fatty acid oxidation and show that the loss of Fyn markedly improves peripheral tissue insulin sensitivity by relieving a selective negative modulation of AMP kinase activity in adipose tissue and skeletal muscle.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2007.04.005