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Comparison of Prevalence of Varicocele in First-Degree Relatives of Patients with Varicocele and Male Kidney Donors

Objectives To evaluate hereditary behavior of varicocele through comparison of prevalence of disease in first-degree relatives of patients with known varicocele and normal healthy kidney donation volunteers. Methods Sixty-two patients with known varicocele who admitted for surgery in Razi Hospital b...

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Published in:Urology (Ridgewood, N.J.) N.J.), 2008-04, Vol.71 (4), p.666-668
Main Authors: Mokhtari, Gholamreza, Pourreza, Farshid, Falahatkar, Siavash, Kamran, Alireza Noshad, Jamali, Maryam
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container_title Urology (Ridgewood, N.J.)
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creator Mokhtari, Gholamreza
Pourreza, Farshid
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Jamali, Maryam
description Objectives To evaluate hereditary behavior of varicocele through comparison of prevalence of disease in first-degree relatives of patients with known varicocele and normal healthy kidney donation volunteers. Methods Sixty-two patients with known varicocele who admitted for surgery in Razi Hospital between September 2005 and October 2006 were enrolled in the study. The patients were asked to refer for examination healthy available first-degree relatives (n = 88). A group of 100 men referred for voluntary kidney donation were selected as control group and assessed for varicocele. Results Of the 88 first-degree relatives of patients with a known varicocele, 40 (45.4%) had a clinically palpable varicocele on physical examination. This was significantly greater than the 11 (11%) of 100 men in the control group ( P
doi_str_mv 10.1016/j.urology.2007.11.116
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Methods Sixty-two patients with known varicocele who admitted for surgery in Razi Hospital between September 2005 and October 2006 were enrolled in the study. The patients were asked to refer for examination healthy available first-degree relatives (n = 88). A group of 100 men referred for voluntary kidney donation were selected as control group and assessed for varicocele. Results Of the 88 first-degree relatives of patients with a known varicocele, 40 (45.4%) had a clinically palpable varicocele on physical examination. This was significantly greater than the 11 (11%) of 100 men in the control group ( P &lt;0.001). Of the first-degree relatives, 32 (55.1%) of 58 brothers and 8 (26.6%) of 30 fathers had palpable varicocele. Conclusions Clinical varicoceles are more prevalent among first-degree relatives (particularly brothers) of patients with known varicoceles and may be an indicator of hereditary behavior of the disease and necessity of screening for male family members.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/j.urology.2007.11.116</identifier><identifier>PMID: 18279919</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Case-Control Studies ; Cohort Studies ; Genetic Predisposition to Disease - genetics ; Gynecology. Andrology. Obstetrics ; Humans ; Inheritance Patterns ; Iran ; Kidney Transplantation ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Non tumoral diseases ; Prevalence ; Tissue Donors ; Urology ; Varicocele - epidemiology ; Varicocele - genetics</subject><ispartof>Urology (Ridgewood, N.J.), 2008-04, Vol.71 (4), p.666-668</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-f8c7645f049fd7b8d88deca3fb0ec241caed1f96afdad04b60af5ae005ae96c3</citedby><cites>FETCH-LOGICAL-c448t-f8c7645f049fd7b8d88deca3fb0ec241caed1f96afdad04b60af5ae005ae96c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=20254341$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18279919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mokhtari, Gholamreza</creatorcontrib><creatorcontrib>Pourreza, Farshid</creatorcontrib><creatorcontrib>Falahatkar, Siavash</creatorcontrib><creatorcontrib>Kamran, Alireza Noshad</creatorcontrib><creatorcontrib>Jamali, Maryam</creatorcontrib><title>Comparison of Prevalence of Varicocele in First-Degree Relatives of Patients with Varicocele and Male Kidney Donors</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>Objectives To evaluate hereditary behavior of varicocele through comparison of prevalence of disease in first-degree relatives of patients with known varicocele and normal healthy kidney donation volunteers. Methods Sixty-two patients with known varicocele who admitted for surgery in Razi Hospital between September 2005 and October 2006 were enrolled in the study. The patients were asked to refer for examination healthy available first-degree relatives (n = 88). A group of 100 men referred for voluntary kidney donation were selected as control group and assessed for varicocele. Results Of the 88 first-degree relatives of patients with a known varicocele, 40 (45.4%) had a clinically palpable varicocele on physical examination. This was significantly greater than the 11 (11%) of 100 men in the control group ( P &lt;0.001). Of the first-degree relatives, 32 (55.1%) of 58 brothers and 8 (26.6%) of 30 fathers had palpable varicocele. Conclusions Clinical varicoceles are more prevalent among first-degree relatives (particularly brothers) of patients with known varicoceles and may be an indicator of hereditary behavior of the disease and necessity of screening for male family members.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Inheritance Patterns</subject><subject>Iran</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Non tumoral diseases</subject><subject>Prevalence</subject><subject>Tissue Donors</subject><subject>Urology</subject><subject>Varicocele - epidemiology</subject><subject>Varicocele - genetics</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkk2P0zAQhi0EYsvCTwDlAreUceLY8QW06rKAWASCFVfLtceLS2oXOynqv8ehFSAuSCN_yM87M3o9hDymsKRA-fPNckpxiLeHZQMglpSW4HfIgnaNqKWU3V2yAJBQs0Z2Z-RBzhsA4JyL--SM9o2QksoFyau43enkcwxVdNXHhHs9YDA4376UBxMNDlj5UF35lMf6Em8TYvUJBz36PeZfqnLEMObqhx-__q3SwVbvS77qnbcBD9VlDDHlh-Se00PGR6f9nNxcvbpZvamvP7x-u7q4rg1j_Vi73gjOOgdMOivWve17i0a3bg1oGkaNRkud5NpZbYGtOWjXaQQoi-SmPSfPjml3KX6fMI9q63Npa9AB45SVACZa2vQF7I6gSTHnhE7tkt_qdFAU1Gy22qiT2Wo2W1Faghfdk1OBab1F-0d1crcAT0-AzkYPLulgfP7NNdB0rGW0cC-PHBY39h6TysbPn2B9QjMqG_1_W3nxTwYz-OBL0W94wLyJUwrFakVVbhSoz_NkzIMBovQAgrY_AcLft68</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Mokhtari, Gholamreza</creator><creator>Pourreza, Farshid</creator><creator>Falahatkar, Siavash</creator><creator>Kamran, Alireza Noshad</creator><creator>Jamali, Maryam</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Comparison of Prevalence of Varicocele in First-Degree Relatives of Patients with Varicocele and Male Kidney Donors</title><author>Mokhtari, Gholamreza ; Pourreza, Farshid ; Falahatkar, Siavash ; Kamran, Alireza Noshad ; Jamali, Maryam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-f8c7645f049fd7b8d88deca3fb0ec241caed1f96afdad04b60af5ae005ae96c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Inheritance Patterns</topic><topic>Iran</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. 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Methods Sixty-two patients with known varicocele who admitted for surgery in Razi Hospital between September 2005 and October 2006 were enrolled in the study. The patients were asked to refer for examination healthy available first-degree relatives (n = 88). A group of 100 men referred for voluntary kidney donation were selected as control group and assessed for varicocele. Results Of the 88 first-degree relatives of patients with a known varicocele, 40 (45.4%) had a clinically palpable varicocele on physical examination. This was significantly greater than the 11 (11%) of 100 men in the control group ( P &lt;0.001). Of the first-degree relatives, 32 (55.1%) of 58 brothers and 8 (26.6%) of 30 fathers had palpable varicocele. Conclusions Clinical varicoceles are more prevalent among first-degree relatives (particularly brothers) of patients with known varicoceles and may be an indicator of hereditary behavior of the disease and necessity of screening for male family members.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18279919</pmid><doi>10.1016/j.urology.2007.11.116</doi><tpages>3</tpages></addata></record>
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subjects Adolescent
Adult
Biological and medical sciences
Case-Control Studies
Cohort Studies
Genetic Predisposition to Disease - genetics
Gynecology. Andrology. Obstetrics
Humans
Inheritance Patterns
Iran
Kidney Transplantation
Male
Male genital diseases
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Non tumoral diseases
Prevalence
Tissue Donors
Urology
Varicocele - epidemiology
Varicocele - genetics
title Comparison of Prevalence of Varicocele in First-Degree Relatives of Patients with Varicocele and Male Kidney Donors
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