Regression of Left Ventricular Hypertrophy following Stenting of Renal Artery Stenosis

Purpose: To determine if angioplasty of atherosclerotic renal artery stenosis, which reduces the activation of the renin-angiotensin-aldosterone system (RAAS), may lead to regression of left ventricular hypertrophy. Methods: The study included 102 patients (58 men; mean age 67 years, range 66–69) wh...

Full description

Saved in:
Bibliographic Details
Published in:Journal of endovascular therapy 2007-04, Vol.14 (2), p.189-197
Main Authors: Zeller, Thomas, Rastan, Aljoscha, Schwarzwälder, Uwe, Müller, Christian, Frank, Ulrich, Bürgelin, Karlheinz, Sixt, Sebastian, Schwarz, Thomas, Noory, Elias, Neumann, Franz-Josef
Format: Article
Language:English
Subjects:
ACE inhibitors
Aged
Angioplasty, Balloon
Atherosclerosis - complications
Atherosclerosis - physiopathology
Atherosclerosis - therapy
Blood Pressure
Case-Control Studies
Female
Follow-Up Studies
Heart failure
Humans
Hypertension
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - etiology
Hypertrophy, Left Ventricular - physiopathology
Hypertrophy, Left Ventricular - therapy
Kidney diseases
Male
Medical imaging
Mortality
Patients
Prognosis
Renal Artery Obstruction - complications
Renal Artery Obstruction - etiology
Renal Artery Obstruction - physiopathology
Renal Artery Obstruction - therapy
Renin-Angiotensin System
Retrospective Studies
Severity of Illness Index
Stents
Time Factors
Treatment Outcome
Ultrasonography
Veins & arteries
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: To determine if angioplasty of atherosclerotic renal artery stenosis, which reduces the activation of the renin-angiotensin-aldosterone system (RAAS), may lead to regression of left ventricular hypertrophy. Methods: The study included 102 patients (58 men; mean age 67 years, range 66–69) who underwent stent-supported percutaneous transluminal renal angioplasty (PTRA) and were included in a clinical follow-up program (mean 24±14 months, range 6–60). As a control group, 101 contemporaneous patients (68 men; mean age 68 years, range 66–70) with essential hypertension were investigated. The primary endpoint was the change in left ventricular mass index (LVMI) determined by echocardiography. Results: Mean follow-up intervals were 24±14 months (range 6–60) in the study group and 27±14 months (range 6–60) in the controls (p=0.09). LVMI decreased significantly by −10±26 g/m2 in the study group, while it increased significantly by 9±28 g/m2 in the control group (p=0.001 between groups). In the study group, mean arterial blood pressure was significantly reduced from 99±11 mmHg to 90±11 mmHg (p
ISSN:1526-6028
1545-1550
DOI:10.1177/152660280701400211