Central AT(1) receptor blockade increases metabolic cost during exercise reducing mechanical efficiency and running performance in rats

The effect of central angiotensin AT(1) receptor blockade on metabolic rate and running performance in rats during exercise on a treadmill (18 m x min(-1), 5% inclination) was investigated. Oxygen consumption (VO(2)) was measured, using the indirect calorimetry system, while the animals were exercis...

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Bibliographic Details
Published in:Neuropeptides (Edinburgh) 2007-06, Vol.41 (3), p.189-194
Main Authors: Leite, Laura H R, Lacerda, Ana Cristina R, Balthazar, Cláudio H, Marubayashi, Umeko, Coimbra, Cândido C
Format: Article
Language:English
Subjects:
Angiotensin II - metabolism
Angiotensin II Type 1 Receptor Blockers - pharmacology
Animals
Biomechanical Phenomena
Body Temperature Regulation - drug effects
Calorimetry, Indirect
Energy Metabolism - drug effects
Injections, Intraventricular
Losartan - pharmacology
Male
Muscle Fatigue - physiology
Oxygen Consumption - drug effects
Physical Exertion - physiology
Rats
Rats, Wistar
Running - physiology
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Summary:The effect of central angiotensin AT(1) receptor blockade on metabolic rate and running performance in rats during exercise on a treadmill (18 m x min(-1), 5% inclination) was investigated. Oxygen consumption (VO(2)) was measured, using the indirect calorimetry system, while the animals were exercising until fatigue after injection of 2 microL of losartan (Los; 60 nmol, n=9), an angiotensin II AT(1) receptor antagonist, or 2 microL of 0.15 M NaCl (Sal, n=9) into the right lateral cerebral ventricle. Mechanical efficiency (ME) and workload (W) were calculated. The W performance by Los-treated animals was 29% lesser than in Sal-treated animals (p
ISSN:0143-4179
DOI:10.1016/j.npep.2007.01.002