Porcine dermatitis and nephropathy syndrome associated with porcine circovirus 2 infection in a Yorkshire pig

We describe a case of porcine dermatitis and nephropathy syndrome (PDNS) in a 14-wk-old Yorkshire pig purchased from a commercial farm for research use. Physical examination of the affected animal upon arrival revealed multifocal, red, papular skin lesions on the rump, vulva, perineum, thighs, and l...

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Bibliographic Details
Published in:Journal of the American Association for Laboratory Animal Science 2007-05, Vol.46 (3), p.68-72
Main Authors: Phaneuf, L.R, Ceccarelli, A, Laing, J.R, Moloo, B, Turner, P.V
Format: Article
Language:English
Subjects:
Animals
Blood Chemical Analysis
Circoviridae Infections - pathology
Circoviridae Infections - veterinary
Circoviridae Infections - virology
Circovirus
dermatitis
Dermatitis - pathology
Dermatitis - veterinary
Dermatitis - virology
Female
histopathology
Immunohistochemistry
kidney diseases
Kidney Diseases - pathology
Kidney Diseases - veterinary
Kidney Diseases - virology
Porcine circovirus
skin lesions
Sus scrofa - anatomy & histology
Sus scrofa - virology
swine
swine diseases
Swine Diseases - pathology
Swine Diseases - virology
Syndrome
Yorkshire (swine breed)
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Summary:We describe a case of porcine dermatitis and nephropathy syndrome (PDNS) in a 14-wk-old Yorkshire pig purchased from a commercial farm for research use. Physical examination of the affected animal upon arrival revealed multifocal, red, papular skin lesions on the rump, vulva, perineum, thighs, and lower hindlegs. At necropsy, gross lesions consisted of dermatitis, bilaterally enlarged kidneys and patchy pulmonary congestion. Histologic findings included multiorgan necrotizing vasculitis with prominent lesions in the skin, kidneys, lung, spleen, and liver. Immunohistochemical staining for porcine circovirus type 2 (PCV2) was strongly positive in affected areas of kidney and spleen. In light of the clinical assessment and gross and histologic findings, a diagnosis of PDNS was made. We emphasize the importance of considering PDNS as a differential diagnosis in laboratory swine with skin lesions.
ISSN:1559-6109
2769-6677