Endothelin-1 in exhaled breath condensate of stable and unstable asthma patients

Summary Endothelins are proinflammatory, profibrotic, broncho- and vasoconstrictive peptides, which play an important role in the development of airway inflammation and remodeling in asthma. The study was undertaken to evaluate the endothelin-1 (ET-1) levels in exhaled breath condensate (EBC) of ast...

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Bibliographic Details
Published in:Respiratory medicine 2008-03, Vol.102 (3), p.470-474
Main Authors: Zietkowski, Z, Skiepko, R, Tomasiak, M.M, Bodzenta-Lukaszyk, A
Format: Article
Language:English
Subjects:
Adult
Asthma
Asthma - diagnosis
Asthma - physiopathology
Biological and medical sciences
Breath Tests - methods
Bronchial Hyperreactivity - diagnosis
Bronchial Hyperreactivity - physiopathology
Case-Control Studies
Cell adhesion & migration
Chronic obstructive pulmonary disease, asthma
Endothelin-1
Endothelin-1 - analysis
Exhaled breath condensate
Exhaled nitric oxide
Female
Humans
Inflammation Mediators - metabolism
Influence
Male
Medical sciences
Middle Aged
Nitric oxide
Nitric Oxide - analysis
Pneumology
Pulmonary/Respiratory
Smooth muscle
Studies
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Summary:Summary Endothelins are proinflammatory, profibrotic, broncho- and vasoconstrictive peptides, which play an important role in the development of airway inflammation and remodeling in asthma. The study was undertaken to evaluate the endothelin-1 (ET-1) levels in exhaled breath condensate (EBC) of asthmatics with different degree in asthma severity. EBC was collected from 31 patients with allergic asthma (11 with steroid-naïve mild asthma, 10 with ICS-treated, stable mild-to-moderate asthma, 10 with ICS-treated unstable, severe asthma) and 7 healthy volunteers. In the three groups of asthmatics, ET-1 concentrations in EBC were significantly higher than in healthy volunteers. ET-1 levels were significantly higher in patients with unstable asthma than in the two groups with stable disease. There was a significant correlation between ET-1 levels and FENO in the three groups of asthmatics and between ET-1 and blood eosinophil counts in the group of patients with unstable asthma. Measurements of ET-1 in EBC may provide another useful diagnostic tool for detecting and monitoring inflammation in patients with asthma.
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2007.10.013