Is Metabolic Syndrome a Risk Factor for Carotid Atherosclerosis in Normotensive and Prehypertensive Individuals?

Aim: We have investigated whether metabolic syndrome is a risk factor for carotid atherosclerosis also in normotensive or prehypertensive individuals. Methods: We analyzed the data from 851 subjects who had a blood pressure of less than 140/90 mmHg and were not taking antihypertensive medication. Me...

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Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2007, Vol.14(2), pp.72-77
Main Authors: Ishizaka, Nobukazu, Ishizaka, Yuko, Toda, Ei-Ichi, Nagai, Ryozo, Yamakado, Minoru
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Atherosclerosis - etiology
Atherosclerosis - physiopathology
Blood Pressure
Carotid Arteries - pathology
Carotid artery
Female
Humans
Japan
Male
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - physiopathology
Middle Aged
Normotension
Prehypertension
Risk Factors
Sex Factors
Tunica Intima - pathology
Tunica Media - pathology
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Summary:Aim: We have investigated whether metabolic syndrome is a risk factor for carotid atherosclerosis also in normotensive or prehypertensive individuals. Methods: We analyzed the data from 851 subjects who had a blood pressure of less than 140/90 mmHg and were not taking antihypertensive medication. Metabolic syndrome was defined according to three different criteria: Japan criteria (Japan-MetS); those of the National Cholesterol Education Program (NCEP)-Adult Treatment Panel III (ATP III) (NCEP-MetS); and modified NCEP-ATP III criteria in which body mass index was used as a surrogate for waist circumference (modified NCEP-MetS). Results: Japan-MetS, NCEP-MetS, and modified NCEP-MetS were found, respectively, in 1%, 4%, and 4%, of women, and in 10%, 5%, and 9%, of men. After the adjustment for gender and age, the association between MetS and carotid atherosclerosis did not reach statistical significance. Conclusion: Although the number of enrolled subjects was relatively small, these data may further support the importance of controlling blood pressure within the optimal range for the purpose of preventing atherosclerosis in individuals with metabolic syndrome.
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.14.72