Intrathyroidal Differentiated Thyroid Carcinoma: Tumor Size‐Based Surgical Concepts

• Published in: World journal of surgery 2007-05, Vol.31 (5), p.888-894
• Main Authors: Miccoli, Paolo, Minuto, Michele N., Ugolini, Clara, Panicucci, Erica, Berti, Piero, Massi, Marco, Basolo, Fulvio
• Format: Article
• Language: English
• Subjects: Adult; Carcinoma, Papillary - pathology; Carcinoma, Papillary - surgery; Evidence-Based Medicine; Female; Humans; Male; Middle Aged; Neck Dissection; Neoplasm Invasiveness; Neoplasm Staging; Papillary Thyroid Cancer; Papillary Thyroid Carcinoma; Retrospective Studies; Thyroid Cancer; Thyroid Carcinoma; Thyroid Neoplasms - pathology; Thyroid Neoplasms - surgery; Thyroidectomy - methods; Total Thyroidectomy; Treatment Outcome
• ISSN: 0364-2313; 1432-2323
• DOI: 10.1007/s00268-006-0795-9

Introduction Total thyroidectomy (TT) remains the treatment of choice for differentiated thyroid carcinomas (DTCs), but a limited approach can be proposed when tumors are at an early stage and limited to a single lobe. The aim of this study was to analyze the pathologic and clinical aspects of a retrospective series of DTCs in an attempt to determine whether these features might prove useful for limiting the surgical strategy in selected cases. Methods From 2000 to 2005, a total of 2798 patients (637 males, 2161 females; mean age 44.6 years) underwent TT for papillary thyroid carcinoma in our department. The histologic features considered were size, histologic subtype and capsule of the tumor, its multifocality/bilaterality, infiltration of the thyroid capsule, and the presence of nodal metastases. Results Statistical analysis revealed that among tumors ≤ 1 cm the presence of the tumor capsule, infiltration of the thyroid capsule, bilaterality, and the presence of node metastases were all significantly lower when the tumor size was ≤ 0.5 cm (p < 0.0001). Furthermore, patients with bilateral carcinomas demonstrated a significantly higher presence of a tumor capsule (p = 0.012), infiltration of the thyroid capsule (p < 0.0001), and node metastases (p < 0.0001) and a higher incidence of the “tall‐cells” variant (p < 0.0001) when compared to the unilateral population. Conclusions Based on these data it is suggested that tumors ≤ 1 cm cannot be considered a homogeneous class of DTCs. Nevertheless, in tumors ≤ 0.5 cm the absence of a “tall‐cells” variant and the absence of infiltration of the thyroid capsule might be useful for avoiding an unnecessary completion thyroidectomy after lobectomy.