Long-term non-invasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndrome

Summary Background Long-term nocturnal non-invasive mechanical ventilation (NIMV) is an effective treatment for obesity-hypoventilation syndrome (OHS), improving central carbon dioxide (CO2 ) sensitivity. Leptin might contribute to sustain adequate ventilation in obesity. The aim of the study was to...

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Bibliographic Details
Published in:Respiratory medicine 2007-06, Vol.101 (6), p.1191-1195
Main Authors: Redolfi, Stefania, Corda, Luciano, La Piana, Giuseppe, Spandrio, Sara, Prometti, Paola, Tantucci, Claudio
Format: Article
Language:English
Subjects:
Aged
Anthropometry
Biological and medical sciences
Carbon Dioxide - blood
Chemosensitivity
Circadian Rhythm
Fasting - blood
Female
Follow-Up Studies
Humans
Hypercapnia - physiopathology
Leptin
Leptin - blood
Leptin - physiology
Male
Medical sciences
Metabolic diseases
Middle Aged
Non-invasive mechanical ventilation
Obesity
Obesity Hypoventilation Syndrome - blood
Obesity Hypoventilation Syndrome - therapy
Obesity-hypoventilation syndrome
Oxygen - blood
Partial Pressure
Pilot Projects
Pneumology
Pulmonary Gas Exchange
Pulmonary/Respiratory
Respiration, Artificial - methods
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Summary:Summary Background Long-term nocturnal non-invasive mechanical ventilation (NIMV) is an effective treatment for obesity-hypoventilation syndrome (OHS), improving central carbon dioxide (CO2 ) sensitivity. Leptin might contribute to sustain adequate ventilation in obesity. The aim of the study was to investigate the role of leptin in the OHS pathogenesis looking at its relationship to CO2 sensitivity before and after NIMV in OHS patients. Methods In six obese patients (3F/3M; aged 63±9 yr; BMI 47.0±4.5 kg/m2 ) with OHS and without obstructive sleep apnoea–hypopnoea (OSAH) diurnal arterial blood gases, fasting plasma leptin concentration and CO2 chemosensitivity were determined before and after 10.3±5.6 (range 6–20) months of NIMV. Results After NIMV improvements were observed in gas exchange (PaO2 from 51.3±6.7 to 75.0±10.3 mmHg, p
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2006.11.005