The rheological properties of pharmaceutical foam: Implications for use

We have evaluated various aerosol foam types having different compositions and related physico-chemical properties. The foams assessed were hydroethanolic, emulsion, and aqueous based. Composition, appearance, loss on drying, and rheological properties were analysed to characterise the macrostructur...

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Bibliographic Details
Published in:International journal of pharmaceutics 2008-05, Vol.355 (1), p.67-80
Main Authors: Kealy, Tim, Abram, Alby, Hunt, Barry, Buchta, Richard
Format: Article
Language:English
Subjects:
Aerosol foam
Aerosol Propellants
Aqueous
Biological and medical sciences
Chemical Phenomena
Chemistry, Pharmaceutical
Chemistry, Physical
Desiccation
Dosage Forms
Emulsion
General pharmacology
Hydroethanolic
Indicators and Reagents
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Reproducibility of Results
Rheology
Stress, Mechanical
Temperature
Topical drug
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Description
Summary:We have evaluated various aerosol foam types having different compositions and related physico-chemical properties. The foams assessed were hydroethanolic, emulsion, and aqueous based. Composition, appearance, loss on drying, and rheological properties were analysed to characterise the macrostructure of the different aerosol foams. To confirm the validity of the vane rheological technique used, and facilitate intuitive understanding of the data, similar data were collected for a commercial shaving foam. Of the physico-chemical parameters that were evaluated, rheological properties were distinct among hydroethanolic, emulsion, and aqueous aerosol foam types. The results indicate that beyond composition differences, physico-chemical differences do exist between these aerosol foam types. The viscoelastic flow properties provided an insight of the macrostructure of materials that have been foamed.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2007.11.057