Increased risk for invasive pneumococcal diseases in children with acute lymphoblastic leukaemia

Summary Asplenia and other conditions of immunodeficiency are established risk factors for invasive pneumococcal disease (IPD). There are no current data available on the risk of IPD in children with acute lymphoblatic leukaemia (ALL), the most common type of childhood malignancy. This study combine...

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Bibliographic Details
Published in:British journal of haematology 2007-06, Vol.137 (5), p.457-460
Main Authors: Meisel, Roland, Toschke, André Michael, Heiligensetzer, Cora, Dilloo, Dagmar, Laws, Hans‐Jürgen, Von Kries, Rüdiger
Format: Article
Language:English
Subjects:
acute lymphoblastic leukaemia
Adolescent
Age Factors
Bacteremia
Bacterial diseases
Biological and medical sciences
Child
Child, Preschool
children
epidemiology
Female
Hematologic and hematopoietic diseases
Human bacterial diseases
Humans
Infectious diseases
invasive pneumococcal disease
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Pneumococcal Infections - immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - microbiology
prophylaxis
Risk
Risk Assessment
Staphylococcal infections, streptococcal infections, pneumococcal infections
Streptococcus pneumoniae
Vaccination
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Summary:Summary Asplenia and other conditions of immunodeficiency are established risk factors for invasive pneumococcal disease (IPD). There are no current data available on the risk of IPD in children with acute lymphoblatic leukaemia (ALL), the most common type of childhood malignancy. This study combined data from a nation‐wide surveillance for IPD and the German childhood cancer registry, and showed that children with ALL carry a more than 10‐fold higher risk for IPD than the general paediatric population. As a substantial proportion of IPD occurs during maintenance chemotherapy, children with ALL may represent candidates for the evaluation of prophylactic interventions including vaccination.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2007.06601.x