Maternal morbidity and infant death in twin vs triplet and quadruplet pregnancies

Objective The purpose of this study was to calculate nationally representative, population-based estimates of maternal and neonatal risks in triplet and quadruplet pregnancies compared with twin pregnancies. Study Design The study population included 316,696 twin, 12,193 triplet, and 778 quadruplet...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2008-04, Vol.198 (4), p.401.e1-401.e10
Main Authors: Luke, Barbara, ScD, MPH, RN, RD, Brown, Morton B., PhD
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cesarean Section
Female
Fetal Membranes, Premature Rupture - epidemiology
Gynecology. Andrology. Obstetrics
Humans
Hypertension - epidemiology
Infant, Newborn
maternal morbidity
Medical sciences
Middle Aged
Morbidity
Obstetrics and Gynecology
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy Complications - mortality
Pregnancy Outcome - epidemiology
Pregnancy, Multiple
Quadruplets
Triplets
Twins
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Summary:Objective The purpose of this study was to calculate nationally representative, population-based estimates of maternal and neonatal risks in triplet and quadruplet pregnancies compared with twin pregnancies. Study Design The study population included 316,696 twin, 12,193 triplet, and 778 quadruplet pregnancies from the 1995-2000 Matched Multiple Birth Data Set. Adjusted odds ratios (AORs) and 95% CIs estimated the risk of complications and were controlled for maternal age, race, parity, and smoking status. Results Compared with mothers of twins, mothers of triplets and quadruplets were more likely to be diagnosed with preterm premature rupture of membranes (AORs, 1.53, 1.74, respectively), pregnancy-associated hypertension (AORs, 1.22, 1.27), and excessive bleeding (AORs, 1.50, 2.22), to require tocolysis (AORs, 2.85, 5.03), and to be delivered by cesarean (AORs, 6.55, 7.38) at
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2007.10.785