Correlation of in Vitro and in Vivo Somatotropic Adenoma Responsiveness to Somatostatin Analogs and Dopamine Agonists with Immunohistochemical Evaluation of Somatostatin and Dopamine Receptors and Electron Microscopy

Objective and Patients: Twenty-four pituitary adenomas from acromegalic patients (13 females, 11 males; age range 19–65 yr) were characterized for somatostatin receptor subtype 2A (sst2A), dopamine D2 receptor (D2R), GH, and prolactin (PRL) expression by immunohistochemistry, and results correlated...

Full description

Saved in:
Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2008-04, Vol.93 (4), p.1412-1417
Main Authors: Ferone, Diego, de Herder, Wouter W., Pivonello, Rosario, Kros, Johan M., van Koetsveld, Peter M., de Jong, Ton, Minuto, Francesco, Colao, Annamaria, Lamberts, Steven W. J., Hofland, Leo J.
Format: Article
Language:English
Subjects:
Adenoma - chemistry
Adenoma - drug therapy
Adenoma - ultrastructure
Adult
Aminoquinolines - therapeutic use
Biological and medical sciences
Dopamine Agonists - therapeutic use
Endocrinopathies
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Growth Hormone-Secreting Pituitary Adenoma - chemistry
Growth Hormone-Secreting Pituitary Adenoma - drug therapy
Growth Hormone-Secreting Pituitary Adenoma - ultrastructure
Human Growth Hormone - blood
Humans
Immunohistochemistry
Male
Medical sciences
Microscopy, Electron
Middle Aged
Octreotide - therapeutic use
Prolactin - blood
Receptors, Dopamine D2 - analysis
Receptors, Somatostatin - analysis
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective and Patients: Twenty-four pituitary adenomas from acromegalic patients (13 females, 11 males; age range 19–65 yr) were characterized for somatostatin receptor subtype 2A (sst2A), dopamine D2 receptor (D2R), GH, and prolactin (PRL) expression by immunohistochemistry, and results correlated with the in vitro and in vivo hormone responses to octreotide and quinagolide. In nine cases, GH and PRL content was further studied by immunoelectron microscopy. Results: Immunoreactivity was semiquantitatively scored as 2 (>50% stained cells), 1 (10–50% stained cells), and 0 (
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2007-1358