Apoptosis induced by the lymphocyte effector molecule perforin

Recent progress has been made in discovering structure/function relationships of the cytotoxic lymphocyte pore-forming protein — perforin — and its role in immune regulation. Long recognized as a key component of the granule exocytosis mechanism of lymphocyte-mediated apoptosis and in host defence a...

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Bibliographic Details
Published in:Current Opinion in Immunology 2007-06, Vol.19 (3), p.339-347
Main Authors: Bolitho, Paul, Voskoboinik, Ilia, Trapani, Joseph A, Smyth, Mark J
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Apoptosis - immunology
Cytotoxicity, Immunologic
Granzymes - immunology
Granzymes - metabolism
Humans
Membrane Glycoproteins - chemistry
Membrane Glycoproteins - immunology
Membrane Glycoproteins - metabolism
Models, Immunological
Perforin
Pore Forming Cytotoxic Proteins - chemistry
Pore Forming Cytotoxic Proteins - immunology
Pore Forming Cytotoxic Proteins - metabolism
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Summary:Recent progress has been made in discovering structure/function relationships of the cytotoxic lymphocyte pore-forming protein — perforin — and its role in immune regulation. Long recognized as a key component of the granule exocytosis mechanism of lymphocyte-mediated apoptosis and in host defence against a variety of pathogens and tumors, more recent attention has focused upon mutations of the perforin gene in some patients with hemophagocytic lymphohistiocytosis. This clinical picture has prompted further work to uncover the molecular structure of perforin and to define its precise role in immune regulation and immunopathology.
ISSN:0952-7915
1879-0372
1365-2567
DOI:10.1016/j.coi.2007.04.007