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Apoptosis induced by the lymphocyte effector molecule perforin

Recent progress has been made in discovering structure/function relationships of the cytotoxic lymphocyte pore-forming protein — perforin — and its role in immune regulation. Long recognized as a key component of the granule exocytosis mechanism of lymphocyte-mediated apoptosis and in host defence a...

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Published in:	Current Opinion in Immunology 2007-06, Vol.19 (3), p.339-347
Main Authors:	Bolitho, Paul, Voskoboinik, Ilia, Trapani, Joseph A, Smyth, Mark J
Format:	Article
Language:	English
Subjects:	Allergy and Immunology Animals Apoptosis - immunology Cytotoxicity, Immunologic Granzymes - immunology Granzymes - metabolism Humans Membrane Glycoproteins - chemistry Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Models, Immunological Perforin Pore Forming Cytotoxic Proteins - chemistry Pore Forming Cytotoxic Proteins - immunology Pore Forming Cytotoxic Proteins - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism
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creator	Bolitho, Paul Voskoboinik, Ilia Trapani, Joseph A Smyth, Mark J
description	Recent progress has been made in discovering structure/function relationships of the cytotoxic lymphocyte pore-forming protein — perforin — and its role in immune regulation. Long recognized as a key component of the granule exocytosis mechanism of lymphocyte-mediated apoptosis and in host defence against a variety of pathogens and tumors, more recent attention has focused upon mutations of the perforin gene in some patients with hemophagocytic lymphohistiocytosis. This clinical picture has prompted further work to uncover the molecular structure of perforin and to define its precise role in immune regulation and immunopathology.
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source	ScienceDirect Freedom Collection 2022-2024; Wiley-Blackwell Read & Publish Collection; PubMed Central
subjects	Allergy and Immunology Animals Apoptosis - immunology Cytotoxicity, Immunologic Granzymes - immunology Granzymes - metabolism Humans Membrane Glycoproteins - chemistry Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Models, Immunological Perforin Pore Forming Cytotoxic Proteins - chemistry Pore Forming Cytotoxic Proteins - immunology Pore Forming Cytotoxic Proteins - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism
title	Apoptosis induced by the lymphocyte effector molecule perforin
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