Low‐dose lenograstim is as effective as standard dose in shortening neutrophil engraftment time following myeloablative chemotherapy and peripheral blood progenitor cell rescue

• Published in: British journal of haematology 2007-06, Vol.137 (5), p.436-442
• Main Authors: Nolan, L., Lorigan, P., Chilton, S., Newman, J., Else, R., Smith, P., Linch, D., Sweetenham, J. W., Johnson, P. W.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Blood Cell Count; CD34; Combined Modality Therapy; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Granulocyte Colony-Stimulating Factor - administration & dosage; Granulocyte Colony-Stimulating Factor - therapeutic use; growth factors; Hematologic and hematopoietic diseases; high‐dose therapy; Hodgkin Disease - drug therapy; Hodgkin Disease - mortality; Hodgkin Disease - surgery; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; lymphoma; Lymphoma, Non-Hodgkin - drug therapy; Lymphoma, Non-Hodgkin - mortality; Lymphoma, Non-Hodgkin - surgery; Male; Medical sciences; Middle Aged; Myeloablative Agonists - therapeutic use; Neutrophils - pathology; Peripheral Blood Stem Cell Transplantation; Prospective Studies; Recombinant Proteins - administration & dosage; Recombinant Proteins - therapeutic use; stem cell transplantation
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/j.1365-2141.2007.06587.x

Summary Granulocyte colony‐stimulating factor (G‐CSF) is widely used following myeloablative chemotherapy (high‐dose therapy; HDT) and peripheral blood progenitor cell rescue (PBPCR) to reduce neutrophil engraftment time. The dose and duration required to gain maximum clinical and economic benefit has not been fully investigated. This double blind placebo‐controlled randomised trial was performed to determine whether short course low‐dose or standard‐dose Lenograstim (L) would influence recovery of haematopoiesis following HDT and PBPCR. Sixty‐one patients were randomised between May 1999 and November 2004, to receive standard‐dose lenograstim (263 μg/d), low‐dose lenograstim (105 μg/d) or placebo injections. These commenced on day +5 following PBPCR and continued until neutrophil engraftment [absolute neutrophil count (ANC)] ≥ 0·5 × 109/l. Patients received standard supportive care until haemopoietic recovery. Both standard‐ and low‐dose lenograstim resulted in a significantly shorter median time to neutrophil recovery (ANC ≥ 0·1 × 109/l:10·0 vs. 11·0 d, P = 0·025; ANC ≥ 0·5 × 109/l:11·0 vs. 14·0 d, P = 0·0002) compared with placebo. There was no significant difference in blood product support, antibiotic usage, documented infection, overall survival or relapse‐free survival between the groups. Short course low‐dose lenograstim is as effective as standard‐dose in reducing neutrophil engraftment time following HDT and PBPCR.