Quantitative cellular description of gastric slow wave activity

Interstitial cells of Cajal (ICC) are responsible for the spontaneous and omnipresent electrical activity in the stomach. A quantitative description of the intracellular processes whose coordinated activity is believed to generate electrical slow waves has been developed and is presented here. In li...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2008-04, Vol.294 (4), p.G989-G995
Main Authors: Corrias, Alberto, Buist, Martin L
Format: Article
Language:English
Subjects:
Animals
Biological Clocks
Calcium Channels - metabolism
Calcium Signaling
Cells
Chloride Channels - metabolism
Computer Simulation
Endoplasmic Reticulum - metabolism
Gastrointestinal diseases
Guinea Pigs
Humans
Kinetics
Mathematical models
Membrane Potentials
Mitochondria - metabolism
Models, Biological
Potassium Channels - metabolism
Reproducibility of Results
Sodium Channels - metabolism
Stomach
Stomach - cytology
Stomach - metabolism
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Summary:Interstitial cells of Cajal (ICC) are responsible for the spontaneous and omnipresent electrical activity in the stomach. A quantitative description of the intracellular processes whose coordinated activity is believed to generate electrical slow waves has been developed and is presented here. In line with recent experimental evidence, the model describes how the interplay between the mitochondria and the endoplasmic reticulum in cycling intracellular Ca(2+) provides the primary regulatory signal for the initiation of the slow wave. The major ion channels that have been identified as influencing slow wave activity have been modeled according to data obtained from isolated ICC. The model has been validated by comparing the simulated profile of the slow waves with experimental recordings and shows good correspondence in terms of frequency, amplitude, and shape in both control and pharmacologically altered conditions.
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.00528.2007