Parenteral microemulsions: An overview

Parenteral delivery of the hydrophobic drugs is a very challenging task. The conventional approaches such as use of co-solvents, oily vehicles and modern approaches such as mixed micelles, liposomes, complexation with cyclodextrins and emulsions have several limitations. Microemulsions have evolved...

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Bibliographic Details
Published in:International journal of pharmaceutics 2008-05, Vol.355 (1), p.19-30
Main Authors: Date, Abhijit A., Nagarsenker, M.S.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical Phenomena
Chemistry, Pharmaceutical
Chemistry, Physical
Drug Delivery Systems
Emulsions - chemistry
General pharmacology
Humans
Hydrophobic drugs
Infusions, Parenteral
Medical sciences
Microemulsions
Nanoparticles - chemistry
Paclitaxel
Parenteral delivery
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Surface-Active Agents - chemistry
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Description
Summary:Parenteral delivery of the hydrophobic drugs is a very challenging task. The conventional approaches such as use of co-solvents, oily vehicles and modern approaches such as mixed micelles, liposomes, complexation with cyclodextrins and emulsions have several limitations. Microemulsions have evolved as a novel vehicle for parenteral delivery of the hydrophobic drugs. Their interesting features such as spontaneity of formation, ease of manufacture, high solubilization capacity and self-preserving property make them the vehicle of choice. The review focuses on the excipients available for formulation of the parenteral microemulsions and describes the investigations reported for the various classes of therapeutic agents.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2008.01.004