quantitative peptide structure vs. retention relationship study

The quantitative relationship between the TLC retention parameters of 28 short peptides and their physicochemical characteristics was calculated using linear regression analysis. It was established that surface parameters exert a significant impact on the retention of peptides and the ratio of non-p...

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Bibliographic Details
Published in:Journal of separation science 2008-04, Vol.31 (6-7), p.1057-1059
Main Authors: Oros, Gyula, Cserháti, Tibor
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical chemistry
Chemical Phenomena
Chemistry
Chemistry, Physical
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Other chromatographic methods
Peptides - chemistry
Quantitative structure retention relationship
Short peptides
Thin-layer chromatography
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Summary:The quantitative relationship between the TLC retention parameters of 28 short peptides and their physicochemical characteristics was calculated using linear regression analysis. It was established that surface parameters exert a significant impact on the retention of peptides and the ratio of non-polar surface area/polar surface area exerts the highest influence on the retention. This result may be due to the fact that peptides turn towards the apolar surface of the stationary phase with their non-polar substructures while the polar molecular parts point into the hydrophilic mobile phase.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.200700636