Application of Biot's theory to ultrasonic characterization of human cancellous bones: Determination of structural,material, and mechanical properties

• Published in: The Journal of the Acoustical Society of America 2008-04, Vol.123 (4), p.2415-2423
• Main Authors: Pakula, Michal, Padilla, Frederic, Laugier, Pascal, Kaczmarek, Mariusz
• Format: Article
• Language: English
• Subjects: Acoustical measurements and instrumentation; Acoustics; Biomechanical Phenomena; Exact sciences and technology; Femur - diagnostic imaging; Fundamental areas of phenomenology (including applications); Humans; Models, Biological; Physics; Porosity; Structural acoustics and vibration; Ultrasonics; Ultrasonography
• ISSN: 0001-4966; 1520-8524
• DOI: 10.1121/1.2839016

This paper is devoted to the experimental determination of distinctive macroscopic structural (porosity, tortuosity, and permeability) and mechanical (Biot-Willis elastic constants) properties of human trabecular bones. Then, the obtained data may serve as input parameters for modeling wave propagation in cancellous bones using Biot's theory. The goal of the study was to obtain experimentally those characteristics for statistically representative group of human bones (35 specimens) obtained from a single skeletal site (proximal femur). The structural parameters were determined using techniques devoted to the characterization of porous materials: electrical spectroscopy, water permeametry, and microcomputer tomography. The macroscopic mechanical properties, Biot-Willis elastic constants, were derived based on the theoretical consideration of Biot's theory, micromechanical statistical models, and experimental results of ultrasonic studies for unsaturated cancellous bones. Our results concerning structural parameters are consistent with the data presented by the other authors, while macroscopic mechanical properties measured within our studies are situated between the other published data. The discrepancies are mainly attributed to different mechanical properties of the skeleton frame, due to strong structural anisotropy varying from site to site. The results enlighten the difficulty to use Biot's theory for modeling wave propagation in cancellous bone, implying necessity of individual evaluation of input parameters.