Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models

Centro Nacional de Biotecnología, Consejo Superior Investigaciones Científicas, Madrid, Spain Calcium is the most universal signal used by living organisms to convey information to many different cellular processes. In this review we present well-known and recently identified proteins that sense and...

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Bibliographic Details
Published in:Physiological reviews 2008-04, Vol.88 (2), p.421-449
Main Authors: Mellstrom, Britt, Savignac, Magali, Gomez-Villafuertes, Rosa, Naranjo, Jose R
Format: Article
Language:English
Subjects:
Animals
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Calcium - metabolism
Calcium Signaling - physiology
Gene Expression Regulation
Protein Modification, Translational
Transcription, Genetic
Online Access:Get full text
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Summary:Centro Nacional de Biotecnología, Consejo Superior Investigaciones Científicas, Madrid, Spain Calcium is the most universal signal used by living organisms to convey information to many different cellular processes. In this review we present well-known and recently identified proteins that sense and decode the calcium signal and are key elements in the nucleus to regulate the activity of various transcriptional networks. When possible, the review also presents in vivo models in which the genes encoding these calcium sensors-transducers have been modified, to emphasize the critical role of these Ca 2+ -operated mechanisms in many physiological functions.
ISSN:0031-9333
1522-1210
DOI:10.1152/physrev.00041.2005