Mass spectrometric analysis of lipopeptides from Bacillus strains isolated from diverse geographical locations

Matrix-assisted laser desorption/ionization time-of-flight MS (MALDI-TOF MS) has been applied to characterize lipopeptide biomarkers from 54 different strains of Bacillis from most taxa within the Bacillis subtilis-Bacillis licheniformis clade, isolated from seven geographic locations on five contin...

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Bibliographic Details
Published in:FEMS microbiology letters 2007-06, Vol.271 (1), p.83-89
Main Authors: Price, Neil P.J, Rooney, Alejandro P, Swezey, James L, Perry, Elizabeth, Cohan, Frederick M
Format: Article
Language:English
Subjects:
antibacterial proteins
Bacillus
Bacillus (bacteria)
Bacillus - chemistry
Bacillus - isolation & purification
Bacteriology
Biological and medical sciences
Biomarkers
Fundamental and applied biological sciences. Psychology
Geographical locations
Ionization
Ions
iturins
Lipopeptides
Lipoproteins - analysis
MALDI
mass spectrometry
matrix assisted laser desorption inoization time of flight mass spectrometry
Metabolism. Enzymes
Microbiology
Molecular Weight
peptides
Polymyxins
Spectrometry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
strains
surfactins
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Summary:Matrix-assisted laser desorption/ionization time-of-flight MS (MALDI-TOF MS) has been applied to characterize lipopeptide biomarkers from 54 different strains of Bacillis from most taxa within the Bacillis subtilis-Bacillis licheniformis clade, isolated from seven geographic locations on five continents. Even the most narrowly defined taxa are diverse in terms of the lipopeptide profiles. Many strains produce previously identified compounds with known antimicrobial properties (e.g. polymyxins and bacitracins), whereas other compounds represent novel classes that were hitherto unknown. Of particular interest is the novel 942/958 Da biomarkers produced by B. s. spizizeni desert strains and several type strains.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2007.00702.x