Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

Multidrug resistance protein (MRP) 4 is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, which are capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell. In addition to its role in the body distribution and renal excretion of...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2008-04, Vol.29 (4), p.200-207
Main Authors: Russel, Frans G.M, Koenderink, Jan B, Masereeuw, Rosalinde
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Binding Sites
Biological Transport
Cell Communication
Cyclic AMP - physiology
Cyclic GMP - physiology
Eicosanoids - metabolism
Humans
Models, Molecular
Multidrug Resistance-Associated Proteins - chemistry
Multidrug Resistance-Associated Proteins - physiology
Signal Transduction
Uric Acid - metabolism
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Summary:Multidrug resistance protein (MRP) 4 is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, which are capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell. In addition to its role in the body distribution and renal excretion of a wide variety of antiviral, cytostatic, antibiotic and cardiovascular drugs, MRP4/ABCC4 has the remarkable ability to transport molecules involved in cellular signalling. These molecules include cyclic nucleotides, eicosanoids, urate and conjugated steroids. The unique structure, regulation and dual localisation of MRP4 in polarised cells could be connected with a key function in cellular protection and extracellular signalling pathways. This review focuses on recent insights into the versatile transport function of MRP4 and its potential as a new therapeutic target to modulate various pathophysiological signalling processes.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2008.01.006