Correlation of Cholestasis With Serum Copper and Whole-Blood Manganese Levels in Pediatric Patients

Many institutions reduce or eliminate copper (Cu) and manganese (Mn) in parenteral nutrition (PN) solutions when cholestasis develops. Little data exist to support this practice. Fifty-four subjects with known serum Cu, whole-blood Mn, and serum-conjugated bilirubin levels were evaluated in this pro...

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Bibliographic Details
Published in:Nutrition in clinical practice 2008-04, Vol.23 (2), p.161-165
Main Authors: McMillan, Nancy B., Mulroy, Cecilia, MacKay, Mark W., McDonald, Catherine M., Jackson, W. Daniel
Format: Article
Language:English
Subjects:
Adolescent
Bilirubin - blood
Body Weight - physiology
Child
Child, Preschool
cholestasis
Cholestasis - blood
copper
Copper - administration & dosage
Copper - blood
Dose-Response Relationship, Drug
Female
Humans
Infant
Male
manganese
Manganese - administration & dosage
Manganese - blood
Nursing
parenteral nutrition
Parenteral Nutrition - adverse effects
pediatric
Prospective Studies
Reference Values
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Summary:Many institutions reduce or eliminate copper (Cu) and manganese (Mn) in parenteral nutrition (PN) solutions when cholestasis develops. Little data exist to support this practice. Fifty-four subjects with known serum Cu, whole-blood Mn, and serum-conjugated bilirubin levels were evaluated in this prospective, observational study. Subjects ranged in weight from 760 g to 65.2 kg. Subjects weighing
ISSN:0884-5336
1941-2452
DOI:10.1177/0884533608314529