Regioselective Palladium Cross-Coupling of 2,4-Dihalooxazoles:  Convergent Synthesis of Trisoxazoles

A regioselective Suzuki−Miyaura cross-coupling of 2,4-dihalooxazoles followed by a Stille coupling has been successfully developed. The procedure affords convergent syntheses of trisoxazoles in high yield and in a minimum number of steps.

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Bibliographic Details
Published in:Journal of organic chemistry 2008-04, Vol.73 (8), p.3303-3306
Main Authors: Ferrer Flegeau, Emmanuel, Popkin, Matthew E., Greaney, Michael F.
Format: Article
Language:English
Subjects:
Bromine - chemistry
Chemistry
Cross-Linking Reagents - chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Iodine - chemistry
Molecular Structure
Organic chemistry
Oxazoles - chemical synthesis
Oxazoles - chemistry
Palladium - chemistry
Preparations and properties
Stereoisomerism
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Description
Summary:A regioselective Suzuki−Miyaura cross-coupling of 2,4-dihalooxazoles followed by a Stille coupling has been successfully developed. The procedure affords convergent syntheses of trisoxazoles in high yield and in a minimum number of steps.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo800121y