Antiretroviral drug resistance among antiretroviral‐naïve persons with recent HIV infection in Thailand

• Published in: HIV medicine 2008-05, Vol.9 (5), p.322-325
• Main Authors: Apisarnthanarak, A, Jirayasethpong, T, Sa‐nguansilp, C, Thongprapai, H, Kittihanukul, C, Kamudamas, A, Tungsathapornpong, A, Mundy, LM
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anti-Retroviral Agents - therapeutic use; antiviral drug resistance; Condoms; Cross-Sectional Studies; Drug Resistance, Viral - drug effects; Drug Resistance, Viral - genetics; drug‐naïve; Female; HIV; HIV Infections - drug therapy; HIV Infections - genetics; HIV Infections - transmission; HIV-1 - drug effects; HIV-1 - genetics; Human immunodeficiency virus; Humans; Male; Middle Aged; Pregnancy; Prospective Studies; recent infection; RNA, Viral - genetics; Sexual Behavior - psychology; Thailand; Viral Load
• ISSN: 1464-2662; 1468-1293
• DOI: 10.1111/j.1468-1293.2008.00562.x

Objectives To evaluate the prevalence and patterns of antiretroviral (ARV) drug resistance (ARV‐DR) among ARV drug‐naïve, recently infected persons with HIV in the 4‐year interval (2003–2006) after the inception of the National Access to ARV Programme for People who have AIDS in Thailand. Methods Cross‐sectional study of patients with recent HIV infection for HIV risks, ARV‐DR risks and baseline ARV‐DR. Results Seven of the 305 patients (2%) had baseline ARV‐DR. Via contract tracing, all seven patients with transmitted ARV‐DR identified sexual partners with prior ARV treatment failure and had documented low (