Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination

To compare the diagnostic accuracy of MnDPDP MR imaging and diffusion-weighted imaging (DWI), alone and in combination, for detecting colorectal liver metastases in patients with suspected metastatic disease. Thirty-three consecutive patients with suspected colorectal liver metastases underwent MR i...

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Bibliographic Details
Published in:European radiology 2008-05, Vol.18 (5), p.903-910
Main Authors: Koh, D. M., Brown, G., Riddell, A. M., Scurr, E., Collins, D. J., Allen, S. D., Chau, I., Cunningham, D., deSouza, N. M., Leach, M. O., Husband, J. E.
Format: Article
Language:English
Subjects:
Accuracy
Aged
Colorectal Neoplasms - pathology
Contrast Media
Diagnostic Radiology
Diffusion Magnetic Resonance Imaging
Edetic Acid - analogs & derivatives
Female
Hepatobiliary-Pancreas
Humans
Imaging
Internal Medicine
Interventional Radiology
Liver
Liver Neoplasms - diagnosis
Liver Neoplasms - secondary
Magnetic Resonance Imaging - methods
Male
Medical research
Medicine
Medicine & Public Health
Metastasis
Middle Aged
Neuroradiology
Observer Variation
Prospective Studies
Pyridoxal Phosphate - analogs & derivatives
Radiology
ROC Curve
Sensitivity and Specificity
Ultrasound
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Description
Summary:To compare the diagnostic accuracy of MnDPDP MR imaging and diffusion-weighted imaging (DWI), alone and in combination, for detecting colorectal liver metastases in patients with suspected metastatic disease. Thirty-three consecutive patients with suspected colorectal liver metastases underwent MR imaging. Three image sets (MnDPDP, DWI and combined MnDPDP and DWI) were reviewed independently by two observers. Lesions were scored on a five-point scale for malignancy and the areas (Az) under the receiver operating characteristic curves were calculated for each observer and image set. The sensitivity and specificity for lesion detection were calculated for each image set and compared. There were 83 metastases, 49 cysts and 1 haemangioma. Using the combined set resulted in the highest diagnostic accuracy for both observers (Az = 0.94 and 0.96), with improved averaged sensitivity of lesion detection compared with the DWI set (p = 0.01), and a trend towards improved sensitivity compared with the MnDPDP set (p = 0.06). There was no difference in the averaged specificity using any of the three image sets (p > 0.5). Combination of MnDPDP MR imaging and DWI resulted in the highest diagnostic accuracy and can increase sensitivity without loss in specificity.
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-007-0847-z