Rheology of Gastric Mucin Exhibits a pH-Dependent Sol−Gel Transition

Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol−gel transition from a vis...

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Bibliographic Details
Published in:Biomacromolecules 2007-05, Vol.8 (5), p.1580-1586
Main Authors: Celli, Jonathan P, Turner, Bradley S, Afdhal, Nezam H, Ewoldt, Randy H, McKinley, Gareth H, Bansil, Rama, Erramilli, Shyamsunder
Format: Article
Language:English
Subjects:
Animals
Applied sciences
Biological and medical sciences
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Gastric Mucins - chemistry
Gels - chemistry
Hydrogen-Ion Concentration
In solution. Condensed state. Thin layers
Molecular biophysics
Natural polymers
Osmolar Concentration
Phase Transition
Physico-chemical properties of biomolecules
Physicochemistry of polymers
Proteins
Rheology
Swine - metabolism
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Summary:Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol−gel transition from a viscoelastic solution at neutral pH to a soft viscoelastic gel in acidic conditions, with the transition occurring near pH 4. In addition to pH-dependent gelation behavior in this system, further rheological studies under nonlinear deformations reveal shear thinning and an apparent yield stress in this material which are also highly influenced by pH.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm0609691