Decoding IgE Fc receptors

Immunoglobulin E (IgE) plays a central role in the pathogenesis of allergic diseases by interacting with two membrane receptors: high-affinity FcepsilonRI and low-affinity FcepsilonRII (CD23). Allergeninduced IgE-occupied FcepsilonRI aggregation on the mast cell or basophil cell surface leads to the...

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Bibliographic Details
Published in:Immunologic research 2007, Vol.37 (1), p.1-16
Main Authors: Zhang, Ming, Murphy, Richard F, Agrawal, Devendra K
Format: Article
Language:English
Subjects:
Affinity
Allergens
Allergic diseases
Allergies
CD23 antigen
Cell surface
Cells
Fc receptors
Gene Expression Regulation
Histamine
Humans
Hypersensitivity - immunology
Hypersensitivity - therapy
Immunoglobulin E
Immunoglobulin E - metabolism
Immunoglobulins
Immunology
Inflammation
Intracellular signalling
Leukocytes (basophilic)
Lipids
Proteins
Receptors
Receptors, Fc - genetics
Receptors, Fc - metabolism
Receptors, IgE - genetics
Receptors, IgE - metabolism
Signal Transduction
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Summary:Immunoglobulin E (IgE) plays a central role in the pathogenesis of allergic diseases by interacting with two membrane receptors: high-affinity FcepsilonRI and low-affinity FcepsilonRII (CD23). Allergeninduced IgE-occupied FcepsilonRI aggregation on the mast cell or basophil cell surface leads to the activation of intracellular signaling events and eventually the release of pre-formed and de novo synthesized inflammatory mediators. The role of FcepsilonRII in allergic diseases has been proposed to include regulation of IgE synthesis, enhanced histamine release from basophils, and a contribution to Ag-IgE complex presentation but the exact function of CD23 remains poorly understood. This review summarizes some new developments in IgE Fc-receptor studies with an emphasis on regulation of FcepsilonRI expression and signal transduction, including monomeric IgE, lipid raft segregation, and some recently identified negative regulators. A better understanding of signaling events following IgE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively.
ISSN:0257-277X
1559-0755
DOI:10.1007/BF02686092