Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia

The effects of chlorogenic acid (CA) on hepatic glucose output, blood glucose levels and on glucose tolerance were analysed. Hepatic uptake of CA and its effects on hepatic catabolism of L‐alanine and glucose‐6‐phosphatase (G‐6‐Pase) activity were also evaluated. CA (1 mM) inhibited about 40% of G‐6...

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Published in:Cell biochemistry and function 2008-04, Vol.26 (3), p.320-328
Main Authors: Bassoli, Bruna Kempfer, Cassolla, Priscila, Borba-Murad, Glaucia Regina, Constantin, Jorgete, Salgueiro-Pagadigorria, Clairce Luzia, Bazotte, Roberto Barbosa, da Silva, Rui Sérgio dos Santos Ferreira, de Souza, Helenir Medri
Format: Article
Language:English
Subjects:
Animals
Area Under Curve
Blood Glucose - drug effects
chlorogenic acid
Chlorogenic Acid - administration & dosage
Chlorogenic Acid - pharmacology
gluconeogenesis
Glucose - biosynthesis
Glucose Tolerance Test
glucose-6-phosphatase
Glucose-6-Phosphatase - metabolism
glycaemia
glycaemic index
Glycerol - metabolism
hepatic glucose release
Hydrogen-Ion Concentration - drug effects
Lactic Acid - metabolism
Liver - drug effects
Liver - enzymology
Liver - metabolism
liver perfusion
Male
Pyruvic Acid - metabolism
Rats
Rats, Wistar
Urea - metabolism
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Summary:The effects of chlorogenic acid (CA) on hepatic glucose output, blood glucose levels and on glucose tolerance were analysed. Hepatic uptake of CA and its effects on hepatic catabolism of L‐alanine and glucose‐6‐phosphatase (G‐6‐Pase) activity were also evaluated. CA (1 mM) inhibited about 40% of G‐6‐Pase activity (p 
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.1444