Effects of calcium ion incorporation on bone healing of Ti6Al4V alloy implants in rabbit tibiae

Abstract The biocompatibility of calcium ion (Ca)-incorporated Ti6Al4V alloy implants, produced by hydrothermal treatment using a Ca-containing solution, was investigated. The surface characteristics were evaluated by scanning electron microscopy, thin-film X-ray diffractometry, Auger electron spect...

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Bibliographic Details
Published in:Biomaterials 2007-08, Vol.28 (22), p.3306-3313
Main Authors: Park, Jin-Woo, Park, Kwang-Bum, Suh, Jo-Young
Format: Article
Language:English
Subjects:
3T3 Cells
Advanced Basic Science
Animals
Biocompatibility
Bone and Bones - drug effects
Bone and Bones - metabolism
Calcium
Calcium - chemistry
Calcium - metabolism
Cell Survival
Cell viability
Coated Materials, Biocompatible - chemistry
Dentistry
Fracture Healing
Histomorphometry
Ions
Mice
Osseointegration
Prostheses and Implants
Rabbits
Surface Properties
Tibia - drug effects
Titanium - chemistry
Titanium alloy
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Summary:Abstract The biocompatibility of calcium ion (Ca)-incorporated Ti6Al4V alloy implants, produced by hydrothermal treatment using a Ca-containing solution, was investigated. The surface characteristics were evaluated by scanning electron microscopy, thin-film X-ray diffractometry, Auger electron spectroscopy, and stylus profilometry. The viability of MC3T3-E1 cells on Ca-incorporated machined Ti6Al4V surfaces with different oxide thicknesses was compared with that on untreated machined Ti6Al4V surfaces with MTT assay. The osteoconductivity of the Ca-incorporated Ti6Al4V implants was evaluated by removal torque testing and histomorphometric analysis after 6 weeks of implantation in rabbit tibiae. Our results show that hydrothermal treatment with a Ca-containing solution produced a crystalline CaTiO3 layer on Ti6Al4V surfaces, and calcium ions were gradually incorporated throughout the oxide layer. After immersion in Hank's balanced salt solution, a considerable apatite deposition was observed on all surfaces of the Ca-incorporated samples. Significant increases in cell viability ( p
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2007.04.007