Loading…
effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women
Objective: To determine the effects of a 15-week high-intensity intermittent exercise (HIIE) program on subcutaneous and trunk fat and insulin resistance of young women. Design and procedures: Subjects were randomly assigned to one of the three groups: HIIE (n=15), steady-state exercise (SSE; n=15)...
Saved in:
Published in: | International Journal of Obesity 2008-04, Vol.32 (4), p.684-691 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c578t-1e572495a492d4acf3a545865a0352385b215ed885fa2a006629ce28b02c87d03 |
---|---|
cites | cdi_FETCH-LOGICAL-c578t-1e572495a492d4acf3a545865a0352385b215ed885fa2a006629ce28b02c87d03 |
container_end_page | 691 |
container_issue | 4 |
container_start_page | 684 |
container_title | International Journal of Obesity |
container_volume | 32 |
creator | Trapp, E.G Chisholm, D.J Freund, J Boutcher, S.H |
description | Objective: To determine the effects of a 15-week high-intensity intermittent exercise (HIIE) program on subcutaneous and trunk fat and insulin resistance of young women. Design and procedures: Subjects were randomly assigned to one of the three groups: HIIE (n=15), steady-state exercise (SSE; n=15) or control (CONT; n=15). HIIE and SSE groups underwent a 15-week exercise intervention. Subjects: Forty-five women with a mean BMI of 23.22.0 kg m-2 and age of 20.22.0 years. Results: Both exercise groups demonstrated a significant improvement (P |
doi_str_mv | 10.1038/sj.ijo.0803781 |
format | article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_70499903</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A190151081</galeid><sourcerecordid>A190151081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c578t-1e572495a492d4acf3a545865a0352385b215ed885fa2a006629ce28b02c87d03</originalsourceid><addsrcrecordid>eNp1ks9vFCEUxydGY9fq1aNONPY22wczDHBsmvojaeJBeyYs82aXDQMVGHX_-7Luxqqp4QDv8fl-gcerqpcElgRacZ62S7sNSxDQckEeVQvS8b5hneSPqwW0wBtgPTupnqW0BQDGgD6tToggkhPRLSqP44gmpzqM9cauN431GX2yeVfvV3GyucS5xp8YjU1Y56itt35dB1-POtcupFRrP5Qg5X3e-jQ762uH39H98t2FueR_hAn98-rJqF3CF8f5tLp5f_X18mNz_fnDp8uL68YwLnJDkHHaSaY7SYdOm7HVrGOiZxpaRlvBVpQwHIRgo6YaoO-pNEjFCqgRfID2tDo7-N7G8G3GlNVkk0HntMcwJ8Whk1JCW8A3_4DbMEdf7qYokZRKzmSB3h6gtXaorB9DqYLZO6oLIoEwAoIUavkAVcaAkzWhVNqW_F-Csz8EG9Qub1Jwc7bBpwedTSzVjjiq22gnHXeKgNq3gUpbVdpAHdugCF4dXzWvJhzu8eO_F-DdEdDJaDdG7cvv_uYo0B5oRwt3fuBS2fJrjPfl-e_Rrw-KUQel17G43nyhQFoAIVkveXsHBdPSRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219229759</pqid></control><display><type>article</type><title>effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women</title><source>Springer Nature - Connect here FIRST to enable access</source><creator>Trapp, E.G ; Chisholm, D.J ; Freund, J ; Boutcher, S.H</creator><creatorcontrib>Trapp, E.G ; Chisholm, D.J ; Freund, J ; Boutcher, S.H</creatorcontrib><description>Objective: To determine the effects of a 15-week high-intensity intermittent exercise (HIIE) program on subcutaneous and trunk fat and insulin resistance of young women. Design and procedures: Subjects were randomly assigned to one of the three groups: HIIE (n=15), steady-state exercise (SSE; n=15) or control (CONT; n=15). HIIE and SSE groups underwent a 15-week exercise intervention. Subjects: Forty-five women with a mean BMI of 23.22.0 kg m-2 and age of 20.22.0 years. Results: Both exercise groups demonstrated a significant improvement (P<0.05) in cardiovascular fitness. However, only the HIIE group had a significant reduction in total body mass (TBM), fat mass (FM), trunk fat and fasting plasma insulin levels. There was significant fat loss (P<0.05) in legs compared to arms in the HIIE group only. Lean compared to overweight women lost less fat after HIIE. Decreases in leptin concentrations were negatively correlated with increases in VO2peak (r=-0.57, P<0.05) and positively correlated with decreases in TBM (r=0.47; P<0.0001). There was no significant change in adiponectin levels after training. Conclusions: HIIE three times per week for 15 weeks compared to the same frequency of SSE exercise was associated with significant reductions in total body fat, subcutaneous leg and trunk fat, and insulin resistance in young women.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0803781</identifier><identifier>PMID: 18197184</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adiponectin - blood ; Adipose Tissue - pathology ; Adiposity - physiology ; Adolescent ; Adult ; Biological and medical sciences ; blood chemistry ; Blood Glucose - metabolism ; Body composition ; Body Composition - physiology ; Body fat ; body fat distribution ; Body Mass Index ; energy expenditure ; Energy Metabolism - physiology ; Epidemiology ; Exercise ; Exercise - physiology ; Fasting - blood ; Female ; Fitness training programs ; Fluorides ; Health aspects ; Health Promotion and Disease Prevention ; Heart Rate - physiology ; high-intensity intermittent exercise ; Humans ; insulin ; Insulin - blood ; Insulin resistance ; insulin secretion ; Internal Medicine ; legs ; leptin ; Leptin - blood ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Methods ; Obesity ; original-article ; Overweight ; Overweight - blood ; Overweight - pathology ; Overweight - rehabilitation ; Physical fitness ; Physical training ; Public Health ; subcutaneous fat ; Subcutaneous Fat - pathology ; torso ; Weight control ; Weight loss ; women ; young adults ; Young women</subject><ispartof>International Journal of Obesity, 2008-04, Vol.32 (4), p.684-691</ispartof><rights>Springer Nature Limited 2008</rights><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-1e572495a492d4acf3a545865a0352385b215ed885fa2a006629ce28b02c87d03</citedby><cites>FETCH-LOGICAL-c578t-1e572495a492d4acf3a545865a0352385b215ed885fa2a006629ce28b02c87d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20260242$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18197184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trapp, E.G</creatorcontrib><creatorcontrib>Chisholm, D.J</creatorcontrib><creatorcontrib>Freund, J</creatorcontrib><creatorcontrib>Boutcher, S.H</creatorcontrib><title>effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Objective: To determine the effects of a 15-week high-intensity intermittent exercise (HIIE) program on subcutaneous and trunk fat and insulin resistance of young women. Design and procedures: Subjects were randomly assigned to one of the three groups: HIIE (n=15), steady-state exercise (SSE; n=15) or control (CONT; n=15). HIIE and SSE groups underwent a 15-week exercise intervention. Subjects: Forty-five women with a mean BMI of 23.22.0 kg m-2 and age of 20.22.0 years. Results: Both exercise groups demonstrated a significant improvement (P<0.05) in cardiovascular fitness. However, only the HIIE group had a significant reduction in total body mass (TBM), fat mass (FM), trunk fat and fasting plasma insulin levels. There was significant fat loss (P<0.05) in legs compared to arms in the HIIE group only. Lean compared to overweight women lost less fat after HIIE. Decreases in leptin concentrations were negatively correlated with increases in VO2peak (r=-0.57, P<0.05) and positively correlated with decreases in TBM (r=0.47; P<0.0001). There was no significant change in adiponectin levels after training. Conclusions: HIIE three times per week for 15 weeks compared to the same frequency of SSE exercise was associated with significant reductions in total body fat, subcutaneous leg and trunk fat, and insulin resistance in young women.</description><subject>Adiponectin - blood</subject><subject>Adipose Tissue - pathology</subject><subject>Adiposity - physiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>blood chemistry</subject><subject>Blood Glucose - metabolism</subject><subject>Body composition</subject><subject>Body Composition - physiology</subject><subject>Body fat</subject><subject>body fat distribution</subject><subject>Body Mass Index</subject><subject>energy expenditure</subject><subject>Energy Metabolism - physiology</subject><subject>Epidemiology</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Fitness training programs</subject><subject>Fluorides</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Heart Rate - physiology</subject><subject>high-intensity intermittent exercise</subject><subject>Humans</subject><subject>insulin</subject><subject>Insulin - blood</subject><subject>Insulin resistance</subject><subject>insulin secretion</subject><subject>Internal Medicine</subject><subject>legs</subject><subject>leptin</subject><subject>Leptin - blood</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Methods</subject><subject>Obesity</subject><subject>original-article</subject><subject>Overweight</subject><subject>Overweight - blood</subject><subject>Overweight - pathology</subject><subject>Overweight - rehabilitation</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Public Health</subject><subject>subcutaneous fat</subject><subject>Subcutaneous Fat - pathology</subject><subject>torso</subject><subject>Weight control</subject><subject>Weight loss</subject><subject>women</subject><subject>young adults</subject><subject>Young women</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp1ks9vFCEUxydGY9fq1aNONPY22wczDHBsmvojaeJBeyYs82aXDQMVGHX_-7Luxqqp4QDv8fl-gcerqpcElgRacZ62S7sNSxDQckEeVQvS8b5hneSPqwW0wBtgPTupnqW0BQDGgD6tToggkhPRLSqP44gmpzqM9cauN431GX2yeVfvV3GyucS5xp8YjU1Y56itt35dB1-POtcupFRrP5Qg5X3e-jQ762uH39H98t2FueR_hAn98-rJqF3CF8f5tLp5f_X18mNz_fnDp8uL68YwLnJDkHHaSaY7SYdOm7HVrGOiZxpaRlvBVpQwHIRgo6YaoO-pNEjFCqgRfID2tDo7-N7G8G3GlNVkk0HntMcwJ8Whk1JCW8A3_4DbMEdf7qYokZRKzmSB3h6gtXaorB9DqYLZO6oLIoEwAoIUavkAVcaAkzWhVNqW_F-Csz8EG9Qub1Jwc7bBpwedTSzVjjiq22gnHXeKgNq3gUpbVdpAHdugCF4dXzWvJhzu8eO_F-DdEdDJaDdG7cvv_uYo0B5oRwt3fuBS2fJrjPfl-e_Rrw-KUQel17G43nyhQFoAIVkveXsHBdPSRA</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Trapp, E.G</creator><creator>Chisholm, D.J</creator><creator>Freund, J</creator><creator>Boutcher, S.H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women</title><author>Trapp, E.G ; Chisholm, D.J ; Freund, J ; Boutcher, S.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-1e572495a492d4acf3a545865a0352385b215ed885fa2a006629ce28b02c87d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adiponectin - blood</topic><topic>Adipose Tissue - pathology</topic><topic>Adiposity - physiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>blood chemistry</topic><topic>Blood Glucose - metabolism</topic><topic>Body composition</topic><topic>Body Composition - physiology</topic><topic>Body fat</topic><topic>body fat distribution</topic><topic>Body Mass Index</topic><topic>energy expenditure</topic><topic>Energy Metabolism - physiology</topic><topic>Epidemiology</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Fitness training programs</topic><topic>Fluorides</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Heart Rate - physiology</topic><topic>high-intensity intermittent exercise</topic><topic>Humans</topic><topic>insulin</topic><topic>Insulin - blood</topic><topic>Insulin resistance</topic><topic>insulin secretion</topic><topic>Internal Medicine</topic><topic>legs</topic><topic>leptin</topic><topic>Leptin - blood</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Methods</topic><topic>Obesity</topic><topic>original-article</topic><topic>Overweight</topic><topic>Overweight - blood</topic><topic>Overweight - pathology</topic><topic>Overweight - rehabilitation</topic><topic>Physical fitness</topic><topic>Physical training</topic><topic>Public Health</topic><topic>subcutaneous fat</topic><topic>Subcutaneous Fat - pathology</topic><topic>torso</topic><topic>Weight control</topic><topic>Weight loss</topic><topic>women</topic><topic>young adults</topic><topic>Young women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trapp, E.G</creatorcontrib><creatorcontrib>Chisholm, D.J</creatorcontrib><creatorcontrib>Freund, J</creatorcontrib><creatorcontrib>Boutcher, S.H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trapp, E.G</au><au>Chisholm, D.J</au><au>Freund, J</au><au>Boutcher, S.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>32</volume><issue>4</issue><spage>684</spage><epage>691</epage><pages>684-691</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Objective: To determine the effects of a 15-week high-intensity intermittent exercise (HIIE) program on subcutaneous and trunk fat and insulin resistance of young women. Design and procedures: Subjects were randomly assigned to one of the three groups: HIIE (n=15), steady-state exercise (SSE; n=15) or control (CONT; n=15). HIIE and SSE groups underwent a 15-week exercise intervention. Subjects: Forty-five women with a mean BMI of 23.22.0 kg m-2 and age of 20.22.0 years. Results: Both exercise groups demonstrated a significant improvement (P<0.05) in cardiovascular fitness. However, only the HIIE group had a significant reduction in total body mass (TBM), fat mass (FM), trunk fat and fasting plasma insulin levels. There was significant fat loss (P<0.05) in legs compared to arms in the HIIE group only. Lean compared to overweight women lost less fat after HIIE. Decreases in leptin concentrations were negatively correlated with increases in VO2peak (r=-0.57, P<0.05) and positively correlated with decreases in TBM (r=0.47; P<0.0001). There was no significant change in adiponectin levels after training. Conclusions: HIIE three times per week for 15 weeks compared to the same frequency of SSE exercise was associated with significant reductions in total body fat, subcutaneous leg and trunk fat, and insulin resistance in young women.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18197184</pmid><doi>10.1038/sj.ijo.0803781</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0307-0565 |
ispartof | International Journal of Obesity, 2008-04, Vol.32 (4), p.684-691 |
issn | 0307-0565 1476-5497 |
language | eng |
recordid | cdi_proquest_miscellaneous_70499903 |
source | Springer Nature - Connect here FIRST to enable access |
subjects | Adiponectin - blood Adipose Tissue - pathology Adiposity - physiology Adolescent Adult Biological and medical sciences blood chemistry Blood Glucose - metabolism Body composition Body Composition - physiology Body fat body fat distribution Body Mass Index energy expenditure Energy Metabolism - physiology Epidemiology Exercise Exercise - physiology Fasting - blood Female Fitness training programs Fluorides Health aspects Health Promotion and Disease Prevention Heart Rate - physiology high-intensity intermittent exercise Humans insulin Insulin - blood Insulin resistance insulin secretion Internal Medicine legs leptin Leptin - blood Medical sciences Medicine Medicine & Public Health Metabolic Diseases Methods Obesity original-article Overweight Overweight - blood Overweight - pathology Overweight - rehabilitation Physical fitness Physical training Public Health subcutaneous fat Subcutaneous Fat - pathology torso Weight control Weight loss women young adults Young women |
title | effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T17%3A43%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=effects%20of%20high-intensity%20intermittent%20exercise%20training%20on%20fat%20loss%20and%20fasting%20insulin%20levels%20of%20young%20women&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Trapp,%20E.G&rft.date=2008-04-01&rft.volume=32&rft.issue=4&rft.spage=684&rft.epage=691&rft.pages=684-691&rft.issn=0307-0565&rft.eissn=1476-5497&rft.coden=IJOBDP&rft_id=info:doi/10.1038/sj.ijo.0803781&rft_dat=%3Cgale_proqu%3EA190151081%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c578t-1e572495a492d4acf3a545865a0352385b215ed885fa2a006629ce28b02c87d03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=219229759&rft_id=info:pmid/18197184&rft_galeid=A190151081&rfr_iscdi=true |