Lipid rafts and membrane traffic

Membrane rafts are regions of increased lipid acyl chain order that differ in their lipid and protein composition from the surrounding membrane. By providing an additional level of compartmentalization they have been proposed to serve many functions in cellular signal transduction and trafficking. W...

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Bibliographic Details
Published in:FEBS letters 2007-05, Vol.581 (11), p.2098-2104
Main Authors: Hanzal-Bayer, Michael F., Hancock, John F.
Format: Article
Language:English
Subjects:
Cell Membrane - chemistry
Cell Membrane - metabolism
Cell Membrane - ultrastructure
Cell Movement - physiology
Cholesterol-facilitated
detergent resistant membranes
DRM
EGF
Endocytosis - physiology
epidermal growth factor
Exocytosis - physiology
fluorescence resonance energy transfer
FRET
GFP
giant unilamellar vesicles
glycosylphosphatidyl-inositol anchored protein
GPI-AP
green fluorescent protein
GUV
HIV
human immunodeficiency virus
liquid-disordered
Liquid-ordered
Membrane Microdomains - chemistry
Membrane Microdomains - metabolism
Membrane microstructure
phosphatidyl-inositol-4,5-bisphosphate
PIP2
pleckstrin homology
Protein Transport - physiology
Rafts
TMD
transmembrane domain
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Summary:Membrane rafts are regions of increased lipid acyl chain order that differ in their lipid and protein composition from the surrounding membrane. By providing an additional level of compartmentalization they have been proposed to serve many functions in cellular signal transduction and trafficking. We will review their potential involvement in different forms of membrane traffic, explicitly excluding signalling, and discuss select aspects of the raft hypothesis in its current form.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2007.03.019