Single‐Dose Chloral Hydrate for Benign Convulsions with Mild Gastroenteritis

Purpose: To reveal the efficacy of single‐dose treatment with chloral hydrate (CH) for clustering seizures in benign convulsions with mild gastroenteritis. Methods: We retrospectively studied the details of treatment in 33 patients with ages ranging from 7 to 39 months. The time‐series records of se...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) 2007-05, Vol.48 (5), p.1026-1028
Main Authors: Enoki, Hideo, Yokota, Takuya, Nagasaki, Rika, Ohro, Yoichiro, Takeda, Sho, Nakashima, Yasumi, Matsubayashi, Rie, Matsubayashi, Tadashi
Format: Article
Language:English
Subjects:
Anticonvulsants - therapeutic use
Benign convulsions with mild gastroenteritis
Biological and medical sciences
Child, Preschool
Children
Chloral hydrate
Chloral Hydrate - administration & dosage
Chloral Hydrate - therapeutic use
Comorbidity
Diazepam
Diazepam - therapeutic use
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Drug toxicity and drugs side effects treatment
Female
Gastroenteritis - drug therapy
Gastroenteritis - epidemiology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Infant
Japan - epidemiology
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Pharmacology. Drug treatments
Retrospective Studies
Seizures - drug therapy
Seizures - epidemiology
Toxicity: nervous system and muscle
Tumors of the nervous system. Phacomatoses
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Summary:Purpose: To reveal the efficacy of single‐dose treatment with chloral hydrate (CH) for clustering seizures in benign convulsions with mild gastroenteritis. Methods: We retrospectively studied the details of treatment in 33 patients with ages ranging from 7 to 39 months. The time‐series records of seizures and processes of drug administrations were investigated. Results: A single‐dose therapy with CH was effective in 19 of 22 patients (86%), and diazepam in two of 16 (13%). The doses of CH in patients having a successful treatment with single‐dose therapy ranged from 41.7 to 62.5 mg/kg (mean 50.2). In two patients, seizures were resistant to single‐dose CH therapy, and their doses of CH were 33.8 and 35.1 mg/kg. Conclusions: An advantage of the single‐dose therapy with CH was shown. We recommend treatment with a sufficient dose of not less than 40 mg/kg of CH.
ISSN:0013-9580
1528-1167
DOI:10.1111/j.1528-1167.2007.01027.x