Preliminary analysis of cold stress responsive proteins in Mesocestoides corti larvae

Many parasites undergo sudden changes in environmental conditions at some stage during their life cycle. The molecular response to this variation is characterised by a rapid transcriptional activation of a specific set of genes coding for proteins generically known as stress proteins. They appear to...

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Bibliographic Details
Published in:Experimental parasitology 2007-07, Vol.116 (3), p.314-319
Main Authors: Canclini, Lucía, Esteves, Adriana
Format: Article
Language:English
Subjects:
2D PAGE
Animals
Biological and medical sciences
Cestoda
Cold Temperature
Electrophoresis, Gel, Two-Dimensional
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Heat-Shock Proteins - analysis
Heat-Shock Proteins - biosynthesis
Heat-Shock Proteins - chemistry
Heat-Shock Proteins - genetics
Helminth Proteins - analysis
Helminth Proteins - biosynthesis
Helminth Proteins - chemistry
Helminth Proteins - genetics
Isoelectric Point
Larva - genetics
Larva - growth & development
Larva - metabolism
Life cycle. Host-agent relationship. Pathogenesis
Male
Mesocestoides - genetics
Mesocestoides - growth & development
Mesocestoides - metabolism
Mice
Molecular Weight
Protein profile
Proteomics
Protozoa
Silver Staining
Starvation
Stress
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Summary:Many parasites undergo sudden changes in environmental conditions at some stage during their life cycle. The molecular response to this variation is characterised by a rapid transcriptional activation of a specific set of genes coding for proteins generically known as stress proteins. They appear to be also involved in various biological processes including cell proliferation and differentiation. The platyhelminth parasite, Mesocestoides corti (Cestoda) presents important properties as a model organism. Under stress conditions, key molecules involved in metabolic pathways as well as in the growth and differentiation of the parasite can be identified. 2D protein expression profile of tetrathyridia of M. corti, submitted to nutritional starvation and cold stress is described, as well as the recovery pattern. A set of specifically expressed proteins was observed in each experimental condition. Quantitative and qualitative differences and stress recovery pattern are also reported. This work makes evident the high plasticity and resistance to extreme environmental conditions of these parasites at the molecular level.
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2007.01.004