Molecular phylogeny of modern coxsackievirus A16

A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7-30.2% and 19.9-25.2% in...

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Bibliographic Details
Published in:Archives of virology 2007-06, Vol.152 (6), p.1201-1208
Main Authors: Perera, D, Yusof, M. A, Podin, Y, Ooi, M. H, Thao, N. T. T, Wong, K. K, Zaki, A, Chua, K. B, Malik, Y. A, Tu, P. V, Tien, N. T. K, Puthavathana, P, McMinn, P. C, Cardosa, M. J
Format: Article
Language:English
Subjects:
Base Sequence
Biological and medical sciences
Capsid Proteins - genetics
Cell culture
Coxsackievirus
DNA Primers - genetics
DNA, Viral - genetics
Enterovirus A, Human - classification
Enterovirus A, Human - genetics
Enterovirus A, Human - isolation & purification
Epidemics
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genomes
Hand, Foot and Mouth Disease - virology
Hospitals
Humans
Medicine
Microbiology
Miscellaneous
Molecular Sequence Data
Phylogenetics
Phylogeny
Viral Structural Proteins - genetics
Virology
Viruses
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Description
Summary:A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7-30.2% and 19.9-25.2% in VP1 and VP4, respectively, in relation to other CVA16 strains, which formed two separate lineages in genogroup B with nucleotide variation of less than 13.4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-006-0934-5