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High-definition genome profiling for genetic marker discovery

Genetic mapping is a key step towards isolating genes and genetic markers associated with phenotypic traits by elucidating their genetic positions. The success of this approach depends on precision in pinpointing genetic positions and the effectiveness of the discovery process. Recent advances in mi...

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Published in:Trends in plant science 2007-05, Vol.12 (5), p.196-202
Main Authors: Zhu, Tong, Salmeron, John
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Language:English
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description Genetic mapping is a key step towards isolating genes and genetic markers associated with phenotypic traits by elucidating their genetic positions. The success of this approach depends on precision in pinpointing genetic positions and the effectiveness of the discovery process. Recent advances in microarray technology and the increasing availability of genomic information have provided an opportunity to use microarrays to scan effectively for genetic variations at the whole-genome scale, enabling the production of high-definition gene-based genetic maps, in combination with functional analyses and identification of trait-associated genetic marker candidates with high precision. In this review, we discuss the concept, process, tools and applications of microarray-based high-definition genetic analysis. This post-genomics approach should help to identify causative genetic variation by uniting genetic and functional information.
doi_str_mv 10.1016/j.tplants.2007.03.013
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subjects Biological and medical sciences
Chromosome Mapping
Crops, Agricultural - genetics
Fundamental and applied biological sciences. Psychology
Genes. Genome
Genetic Markers
genetic variation
Genomics - methods
literature reviews
microarray technology
Molecular and cellular biology
Molecular genetics
Oligonucleotide Array Sequence Analysis
plant genetics
Polymorphism, Genetic
single feature polymorphisms
title High-definition genome profiling for genetic marker discovery
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