First report of diffuse cutaneous leishmaniasis and Leishmania amazonensis infection in Rio de Janeiro State, Brazil

Diffuse cutaneous leishmaniasis (DCL) is characterised by multiple and progressive cutaneous lesions, resistance to chemotherapy and Leishmania-specific T-cell anergy. We report the first autochthonous DCL case and the first human infection with Leishmania amazonensis in Rio de Janeiro State, Brazil...

Full description

Saved in:
Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2007-07, Vol.101 (7), p.735-737
Main Authors: Azeredo-Coutinho, R.B.G., Conceição-Silva, F., Schubach, A., Cupolillo, E., Quintella, L.P., Madeira, M.F., Pacheco, R.S., Valete-Rosalino, C.M., Mendonça, S.C.F.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brazil
Brazil - epidemiology
Child
Diffuse cutaneous leishmaniasis
Human protozoal diseases
Humans
Infectious diseases
Isoenzymes
Leishmania - isolation & purification
Leishmania amazonensis
Leishmaniasis, Diffuse Cutaneous - diagnosis
Leishmaniasis, Diffuse Cutaneous - epidemiology
Leishmaniasis, Diffuse Cutaneous - parasitology
Leshmaniasis
Male
Medical sciences
Parasitic diseases
PCR
Protozoal diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diffuse cutaneous leishmaniasis (DCL) is characterised by multiple and progressive cutaneous lesions, resistance to chemotherapy and Leishmania-specific T-cell anergy. We report the first autochthonous DCL case and the first human infection with Leishmania amazonensis in Rio de Janeiro State, Brazil, where only L. braziliensis is considered to be the causative agent of cutaneous leishmaniasis. Leishmania amazonensis was identified by multilocus enzyme electrophoresis and PCR-RFLP. Our case was diagnosed as DCL according to clinical, parasitological, histopathological and immunological criteria. These observations indicate that L. amazonensis is increasing its geographical distribution in Brazil, accounting for unusual clinical presentations in new transmission areas.
ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2007.01.005