Improving the comparability of immunoassays for prostate-specific antigen (PSA): Progress and problems

Commutability of immunoassay test results is an important objective for laboratory medicine. PSA is a clinically important analyte for which, as a consequence of a number of national and international initiatives over the last decade, considerable progress has been made towards improving method comp...

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Bibliographic Details
Published in:Clinica chimica acta 2007-05, Vol.381 (1), p.85-92
Main Authors: Sturgeon, Catharine M., Ellis, Andrew R.
Format: Article
Language:English
Subjects:
Animals
Between-method agreement
Biomarkers - analysis
EQA
Equimolarity
Free PSA
Humans
Immunoassay - standards
Male
Method comparability
Prostate-Specific Antigen - analysis
Prostatic Neoplasms - diagnosis
PSA
Reproducibility of Results
Standardization
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Summary:Commutability of immunoassay test results is an important objective for laboratory medicine. PSA is a clinically important analyte for which, as a consequence of a number of national and international initiatives over the last decade, considerable progress has been made towards improving method comparability. However, results from different assays are still not interchangeable, a situation that is only likely to improve once broad recommendations can be made about the most clinically relevant antibody combinations. Universal implementation of such recommendations would almost certainly improve between-method agreement substantially, provided careful attention were paid to assay design and use of appropriately pure secondary standards ensured.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2007.02.015