Chemically Immobilized Single-Stranded Oligonucleotides on Praseodymium Oxide Nanoparticles as an Unlabeled DNA Sensor Probe Using Impedance

A spark of attraction: Ellipsoidal Pr6O11 particles on indium tin oxide (ITO) modified with single‐stranded oliogonucleotides act as an unlabeled DNA probe. Upon recognition of complementary bases in solution, an impedance change (capacitance change) is detected. An equivalent impedance change is no...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2007-01, Vol.46 (21), p.3855-3859
Main Authors: Shrestha, Sudha, Yeung, Connie M. Y., Mills, Catherine E., Lewington, Jay, Tsang, Shik Chi
Format: Article
Language:English
Subjects:
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
DNA Probes - chemistry
DNA structures
Electric Impedance
electrochemistry
label‒free reagents
Molecular Structure
Nanoparticles - chemistry
Oligonucleotides - chemistry
Oxides - chemistry
Particle Size
Praseodymium - chemistry
praseodymium oxide
Sensitivity and Specificity
surface chemistry
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Summary:A spark of attraction: Ellipsoidal Pr6O11 particles on indium tin oxide (ITO) modified with single‐stranded oliogonucleotides act as an unlabeled DNA probe. Upon recognition of complementary bases in solution, an impedance change (capacitance change) is detected. An equivalent impedance change is not obtained upon the addition of an oligonucleotide with slightly mismatched bases.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200604827