Colorimetric Detection of Mercuric Ion (Hg2+) in Aqueous Media using DNA-Functionalized Gold Nanoparticles

Color is everything: Hg2+ in aqueous media is detected by the formation of thymidine–Hg2+–thymidine coordination complexes, which raises the melting temperature of the DNA‐hybridized gold nanoparticle probes and thus the temperature at which the probes disperse and effect a purple‐to‐red color chang...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2007-01, Vol.46 (22), p.4093-4096
Main Authors: Lee, Jae-Seung, Han, Min Su, Mirkin, Chad A.
Format: Article
Language:English
Subjects:
Biosensing Techniques - methods
Cations, Divalent
colorimetric detection
Colorimetry - methods
DNA
DNA - chemistry
Gold - chemistry
mercury
Mercury - analysis
Mercury - chemistry
Models, Molecular
nanoparticles
Nanoparticles - chemistry
sensors
Temperature
Water - chemistry
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Summary:Color is everything: Hg2+ in aqueous media is detected by the formation of thymidine–Hg2+–thymidine coordination complexes, which raises the melting temperature of the DNA‐hybridized gold nanoparticle probes and thus the temperature at which the probes disperse and effect a purple‐to‐red color change. The method has very high sensitivity and selectivity, and it provides a simple and fast colorimetric readout (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200700269