Serotonin and 5-hydroxy indole acetic acid in infantile hydrocephalus

The concentration of metabolites of neurohormones in cerebrospinal fluid (CSF) is an index of turnover of substances in brain parenchyma. The raised intracranial pressure in hydrocephalic children may cause alteration in the metabolism of neurohormones. Serotonin and its metabolite 5-HIAA have been...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric surgery international 2007-06, Vol.23 (6), p.571-574
Main Authors: Gopal, S C, Sharma, V, Chansuria, J P N, Gangopadhyaya, A N, Singh, T B
Format: Article
Language:English
Subjects:
Biomarkers - cerebrospinal fluid
Case-Control Studies
Humans
Hydrocephalus
Hydrocephalus - diagnosis
Hydrocephalus - metabolism
Hydrocephalus - surgery
Hydroxyindoleacetic Acid - cerebrospinal fluid
Infant
Matched-Pair Analysis
Pilot Projects
Prognosis
Serotonin
Serotonin - cerebrospinal fluid
Ventriculoperitoneal Shunt
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The concentration of metabolites of neurohormones in cerebrospinal fluid (CSF) is an index of turnover of substances in brain parenchyma. The raised intracranial pressure in hydrocephalic children may cause alteration in the metabolism of neurohormones. Serotonin and its metabolite 5-HIAA have been studied extensively in CSF of patients with neuropsychiatric diseases. Hence we studied the neurohormones serotonin and its end product 5-hydroxy indole acetic acid (5-HIAA) in CSF of hydrocephalus infants before and after ventriculoperitoneal (VP) shunt. Ventricular CSF samples form 50 hydrocephalic infants were obtained serially at the time of shunt insertion, and then on day 8 and day 30 postoperatively by direct puncture from shunt chamber using 26G needles. Control CSF samples were taken from otherwise healthy children operated under spinal anesthesia. The samples were analyzed for serotonin and 5-HIAA by spectrofluorophotometric method. At the time of shunt insertion, serotonin was significantly decreased (P
ISSN:0179-0358
1437-9813
DOI:10.1007/s00383-006-1689-5