Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender

Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V...

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Bibliographic Details
Published in:Journal of lipid research 2008-05, Vol.49 (5), p.945-953
Main Authors: Olano-Martin, Estibaliz, Abraham, Elizheeba C, Gill-Garrison, Rosalynn, Valdes, Ana M, Grimaldi, Keith, Tang, Fiona, Jackson, Kim G, Williams, Christine M, Minihane, Anne M
Format: Article
Language:English
Subjects:
Adult
Aged
Apolipoprotein A-V
Apolipoproteins A - genetics
Fatty Acids, Nonesterified - blood
Female
Genetic Variation
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Postprandial Period
Sex Characteristics
Triglycerides - blood
United Kingdom
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Summary:Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender x genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males. Lower HDL-cholesterol was associated with the rare TC genotype (P = 0.047). Significant linkage disequilibrium was found between the apoA-V -1131 T>C and the apoC-III 3238 C>G variants, with univariate analysis indicating an impact of this apoC-III single nucleotide polymorphism (SNP) on TG AUC (P = 0.015). However, in linear regression analysis, a significant independent association with TG AUC (P = 0.007) was only evident for the apoA-V -1131 T>C SNP, indicating a greater relative importance of the apoA-V genotype.
ISSN:0022-2275
1539-7262
DOI:10.1194/jlr.M700112-JLR200