Reduced parietal and visual cortical activation during global processing in Williams syndrome

Several lines of investigation suggest that individuals with Williams syndrome (WS), a neurodevelopmental disorder of well‐characterized genetic etiology, have selective impairments in integrating local image elements into global configurations. We compared global processing abilities in 10 clinical...

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Bibliographic Details
Published in:Developmental medicine and child neurology 2007-06, Vol.49 (6), p.433-438
Main Authors: Mobbs, Dean, Eckert, Mark A, Menon, Vinod, Mills, Debbie, Korenberg, Julie, Galaburda, Albert M, Rose, Fred E, Bellugi, Ursula, Reiss, Allan L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cerebellum - anatomy & histology
Cerebellum - physiopathology
Cognition Disorders - diagnosis
Cognition Disorders - epidemiology
Cognition Disorders - physiopathology
Etiology
Exhibits
Female
Females
Freehand Drawing
Functional Laterality
Humans
Hyperacusis - prevention & control
In Situ Hybridization, Fluorescence
Intelligence Quotient
Magnetic Resonance Imaging
Male
Males
Mathematical Aptitude
Middle Aged
Neural Pathways - anatomy & histology
Neural Pathways - physiopathology
Parietal Lobe - anatomy & histology
Parietal Lobe - physiopathology
Severity of Illness Index
Stimuli
Thalamus - anatomy & histology
Thalamus - physiopathology
Verbal Ability
Visual Cortex - anatomy & histology
Visual Cortex - physiopathology
Wechsler Scales
Williams Syndrome - epidemiology
Williams Syndrome - genetics
Williams Syndrome - physiopathology
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Summary:Several lines of investigation suggest that individuals with Williams syndrome (WS), a neurodevelopmental disorder of well‐characterized genetic etiology, have selective impairments in integrating local image elements into global configurations. We compared global processing abilities in 10 clinically and genetically diagnosed participants with WS (eight females, two males; mean age 31y 10mo [SD 9y 7mo], range 15y 5mo‐48y 4mo) with a typically developed (TD) age‐ and sex‐matched comparison group (seven females, one male; mean age 35y 2mo [SD 10y 10mo], range 24y‐54y 7mo) using functional magnetic resonance imaging (fMRI). Behavioral data showed participants with WS to be significantly less accurate (p
ISSN:0012-1622
1469-8749
DOI:10.1111/j.1469-8749.2007.00433.x