Synthesis and antigenotoxic activity of some naphtho[2,1- b]pyrano[3,2- e][1,2,4]triazolo[1,5- c]pyrimidine derivatives

In this study, some pyranotriazolopyrimidine derivatives were synthesised by reacting ethoxymethyleneamino derivatives with hydrazides. Their structures were elucidated by IR, 1H NMR, and 13C NMR spectroscopic data and elemental analyses. Antigenotoxic activity of the obtained compounds was tested i...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2007-05, Vol.42 (5), p.715-718
Main Authors: Chabchoub, Fakher, Messaâd, Mehdi, Ben Mansour, Hédi, Chekir-Ghedira, Leila, Salem, Mansour
Format: Article
Language:English
Subjects:
Antigenotoxic activity
Antimutagenic Agents - chemical synthesis
Antimutagenic Agents - pharmacology
Biological and medical sciences
Escherichia coli - drug effects
General aspects. Methods
Iminoethers
Magnetic Resonance Spectroscopy
Medical sciences
Pyrimidines - chemical synthesis
Pyrimidines - pharmacology
SOS chromotest
Spectrophotometry, Infrared
Toxicology
Triazolopyrimidines
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Summary:In this study, some pyranotriazolopyrimidine derivatives were synthesised by reacting ethoxymethyleneamino derivatives with hydrazides. Their structures were elucidated by IR, 1H NMR, and 13C NMR spectroscopic data and elemental analyses. Antigenotoxic activity of the obtained compounds was tested in Escherichia coli PQ37 by using the SOS chromotest. [Display omitted]
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2006.12.002