Loading…

Glomerular size in renal dysplasia secondary to obstructive uropathy: A further exploration of the fetal lamb model

Background/Purpose: Creating an obstructive uropathy early in glomerulogenesis would produce multicystic dysplastic kidneys (MCDK). Measuring the mean planar area of the glomeruli (GMPA) may clarify the pathogenesis of MCDK. Methods: Fetal lambs at 60 days' gestation had their left ureter ligat...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pediatric surgery 2000-11, Vol.35 (11), p.1651-1655
Main Authors: Kitagawa, Hiroaki, Pringle, Kevin C., Zuccollo, Jane, Koike, Junki, Nakada, Koonosuke, Ikoma, Masaaki, Seki, Yasuji
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Purpose: Creating an obstructive uropathy early in glomerulogenesis would produce multicystic dysplastic kidneys (MCDK). Measuring the mean planar area of the glomeruli (GMPA) may clarify the pathogenesis of MCDK. Methods: Fetal lambs at 60 days' gestation had their left ureter ligated and were delivered by cesarian section at 145 days' gestation. Kidney weight and length were recorded. GMPA in 3 zones (outer, middle, inner) of the sectioned kidney was measured using a computerized planimeter. The obstructed kidneys were compared with contralateral unobstructed kidneys. The unpaired Student's t test was used to determine significance. Results: One ewe miscarried. Four of 5 (80%) 60-day lambs survived. All had dysplastic kidneys. Mean kidney weights were 4.3 ± 0.84 g in MCDK and 16.8 ± 3.6 g in controls (P
ISSN:0022-3468
1531-5037
DOI:10.1053/jpsu.2000.18344