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Glomerular size in renal dysplasia secondary to obstructive uropathy: A further exploration of the fetal lamb model
Background/Purpose: Creating an obstructive uropathy early in glomerulogenesis would produce multicystic dysplastic kidneys (MCDK). Measuring the mean planar area of the glomeruli (GMPA) may clarify the pathogenesis of MCDK. Methods: Fetal lambs at 60 days' gestation had their left ureter ligat...
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Published in: | Journal of pediatric surgery 2000-11, Vol.35 (11), p.1651-1655 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background/Purpose: Creating an obstructive uropathy early in glomerulogenesis would produce multicystic dysplastic kidneys (MCDK). Measuring the mean planar area of the glomeruli (GMPA) may clarify the pathogenesis of MCDK. Methods: Fetal lambs at 60 days' gestation had their left ureter ligated and were delivered by cesarian section at 145 days' gestation. Kidney weight and length were recorded. GMPA in 3 zones (outer, middle, inner) of the sectioned kidney was measured using a computerized planimeter. The obstructed kidneys were compared with contralateral unobstructed kidneys. The unpaired Student's t test was used to determine significance. Results: One ewe miscarried. Four of 5 (80%) 60-day lambs survived. All had dysplastic kidneys. Mean kidney weights were 4.3 ± 0.84 g in MCDK and 16.8 ± 3.6 g in controls (P |
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ISSN: | 0022-3468 1531-5037 |
DOI: | 10.1053/jpsu.2000.18344 |