Distension‐induced gastric accommodation in functional dyspepsia: effect of autonomic manipulation

Functional dyspepsia (FD) is associated with impaired gastric accommodation and autonomic dysregulation. The aim of this study was to investigate the effects of autonomic manipulation on distension‐induced gastric accommodation in subjects with and without FD, using a newly developed gastric barosta...

Full description

Saved in:
Bibliographic Details
Published in:Neurogastroenterology and motility 2007-05, Vol.19 (5), p.365-375
Main Authors: Lunding, J. A., Gilja, O. H., Hausken, T., Bayati, A., Mattsson, H., Berstad, A.
Format: Article
Language:English
Subjects:
Animals
atropine
Atropine - metabolism
Autonomic Nervous System - physiology
barostat
Dyspepsia - physiopathology
gastric accommodation
Gastric Dilatation
gastric distension
Heart Rate - physiology
Humans
Parasympatholytics - metabolism
Pressure
Stomach - anatomy & histology
Stomach - physiology
stress
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Functional dyspepsia (FD) is associated with impaired gastric accommodation and autonomic dysregulation. The aim of this study was to investigate the effects of autonomic manipulation on distension‐induced gastric accommodation in subjects with and without FD, using a newly developed gastric barostat paradigm. Twelve healthy subjects (HS) and 18 subjects with FD had four barostat examinations each: no intervention, intravenous atropine (1 mg), vagal stimulation (mental relaxation with deep breathing) and acute stress stimulation (serial subtraction task). Intrabag pressure increased from 1 to 15 mmHg in 5 min (ramp phase), and was maintained at 15 mmHg for 5 min (tonic phase). Volume responses were analysed using predefined parameters. There were no significant group differences in accommodation variables between HS and subjects with FD. The FD group could be subdivided into two distinct subgroups: subgroup 1 (n = 7, 38%) with low maximum volume and accommodation rate, and subgroup 2 with normal accommodation (n = 11). In subgroup 1, but not in subgroup 2 atropine increased maximum volume and accommodation rate substantially. Neither mental stress nor mental relaxation changed any of the accommodation variables. In a subgroup of subjects with FD, impairment of distension‐induced gastric accommodation can be improved by cholinergic blockade, but not by acute physiological autonomic manipulation.
ISSN:1350-1925
1365-2982
DOI:10.1111/j.1365-2982.2006.00896.x