Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy

Summary Thymic stromal‐derived lymphopoietin (TSLP) and interleukin‐7 share a common receptor chain, IL‐7Rα. IL‐7 is involved in T‐cell homeostasis, and TSLP induces production of pro‐allergic cytokines. The gene encoding the IL‐7Rα chain is polymorphic, and investigation of inhalation allergic pati...

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Bibliographic Details
Published in:International Journal of Immunogenetics 2007-06, Vol.34 (3), p.149-151
Main Authors: Shamim, Z., Müller, K., Svejgaard, A., Poulsen, L. K., Bodtger, U., Ryder, L. P.
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Denmark - epidemiology
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Interleukin-7 - genetics
Respiratory Hypersensitivity - epidemiology
Respiratory Hypersensitivity - genetics
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Summary:Summary Thymic stromal‐derived lymphopoietin (TSLP) and interleukin‐7 share a common receptor chain, IL‐7Rα. IL‐7 is involved in T‐cell homeostasis, and TSLP induces production of pro‐allergic cytokines. The gene encoding the IL‐7Rα chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.
ISSN:1744-3121
1744-313X
1365-2370
DOI:10.1111/j.1744-313X.2007.00657.x